Evaluation of 3D image registration as applied to MR-guided thermal treatment of liver cancer

David L. Wilson, Andres Carrillo, Lan Zheng, Ahmet Genc, Jeffrey L. Duerk, Jonathan S. Lewin

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


There are many potential applications of three-dimensional (3D) image registration in MR-guided radiofrequency (RF) thermal ablation of tumors. For example, after registration of image volumes obtained before and after thermal ablation, a variety of quantitative and visual assessments of therapy were performed. For liver tumors, the accuracy of rigid body, manual registration on 19 pairs of image volumes was evaluated, almost all of which were obtained during thermal treatment sessions. Registration error was estimated as a distance between anatomical landmarks, including both internal vascular structures as well as the surface of the liver. Over all image pairs and throughout a large portion of the liver, the registration error was 3.1 mm (mean + 1 SD). From the bottom to the top of the liver, error increased on the order of 13%, probably because of liver motion and deformation resulting from respiration. Although probably insufficient for blind guidance of therapy, registration accuracy was undoubtedly sufficient for interesting applications in the planning, assessment, and optimization of interventional MR-guided thermal treatment of liver tumors.

Original languageEnglish (US)
Pages (from-to)77-84
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Issue number1
StatePublished - Jan 1998
Externally publishedYes


  • 3D image registration
  • Cancer therapy
  • Interventional MRI
  • Medical Image analysis
  • RF thermal ablation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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