Evaluation and Management of Laryngopharyngeal Reflux Disease: State of the Art Review

Jerome R. Lechien, Lee M. Akst, Abdul Latif Hamdan, Antonio Schindler, Petros D. Karkos, Maria Rosaria Barillari, Christian Calvo-Henriquez, Lise Crevier-Buchman, Camille Finck, Young Gyu Eun, Sven Saussez, Michael F. Vaezi

Research output: Contribution to journalReview articlepeer-review

76 Scopus citations


Objective: To review the current literature about the epidemiology, clinical presentation, diagnosis, and treatment of laryngopharyngeal reflux (LPR). Data Sources: PubMed, Cochrane Library, and Scopus. Methods: A comprehensive review of the literature on LPR epidemiology, clinical presentation, diagnosis, and treatment was conducted. Using the PRISMA statement, 3 authors selected relevant publications to provide a critical analysis of the literature. Conclusions: The important heterogeneity across studies in LPR diagnosis continues to make it difficult to summarize a single body of thought. Controversies persist concerning epidemiology, clinical presentation, diagnosis, and treatment. No recent epidemiologic study exists regarding prevalence and incidence with the use of objective diagnostic tools. There is no survey that evaluates the prevalence of symptoms and signs on a large number of patients with confirmed LPR. Regarding diagnosis, an increasing number of authors used multichannel intraluminal impedance–pH monitoring, although there is no consensus regarding standardization of the diagnostic criteria. The efficiency of proton pump inhibitor (PPI) therapy remains poorly demonstrated and misevaluated by incomplete clinical tools that do not take into consideration many symptoms and extralaryngeal findings. Despite the recent advances in knowledge about nonacid LPR, treatment protocols based on PPIs do not seem to have evolved. Implications for Practice: The development of multichannel intraluminal impedance–pH monitoring and pepsin and bile salt detection should be considered for the establishment of a multiparameter diagnostic approach. LPR treatment should evolve to a more personalized regimen, including diet, PPIs, alginate, and magaldrate according to individual patient characteristics. Multicenter international studies with a standardized protocol could improve scientific knowledge about LPR.

Original languageEnglish (US)
Pages (from-to)762-782
Number of pages21
JournalOtolaryngology - Head and Neck Surgery (United States)
Issue number5
StatePublished - May 1 2019


  • gastroesophageal
  • laryngitis
  • laryngopharyngeal reflux

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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