Abstract
Pretibial myxedema is typically associated with clinical hyperthyroidism, diffuse goiter, and ophthalmopathy in patients with Graves' disease. A case of biopsy-proved pretibial myxedema was encountered in a clinically euthyroid woman who had neither diffuse goiter nor exophthalmos. Although serum total and free thyroxine hormone concentrations were normal, the thyroid-stimulating hormone response to thyrotropin-releasing hormone was absent. This case illustrates that pretibial myxedema may present without other more common manifestations of Graves' disease. In patients with suspect pretibial skin lesions, the thyrotropin-releasing hormone stimulation test may be required to establish the presence of subtle underlying thyroid gland autonomy and the diagnosis of euthyroid pretibial myxedema.
Original language | English (US) |
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Pages (from-to) | 318-320 |
Number of pages | 3 |
Journal | The American journal of medicine |
Volume | 82 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1987 |
Externally published | Yes |
ASJC Scopus subject areas
- General Medicine