Etiology, Epidemiology, and Pathophysiology of Post-Facial Paralysis Synkinesis

Kofi D.O. Boahene

doi:10.1016/B978-0-323-67331-0.00002-6

Etiology, Epidemiology, and Pathophysiology of Post-Facial Paralysis Synkinesis

Kofi D.O. Boahene

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The pathological mechanism of synkinesis following facial paralysis is not completely understood. Consequently, current treatment options have mixed efficacy. The main pathophysiologic mechanisms of synkinesis-aberrant regeneration of facial nerve fibers, ephaptic transmission of impulses, and somatotopic reorganization of the facial nucleus- underscores the challenges in establishing effective treatment for synkinesis. More recently, enhanced understanding of the electrophysiologic alterations in peripheral nerves post injury has opened new opportunities for therapeutic targeting and more effective treatment of synkinesis.

Original language	English (US)
Title of host publication	Management of Post-Facial Paralysis Synkinesis
Publisher	Elsevier
Pages	13-17
Number of pages	5
ISBN (Electronic)	9780323673310
ISBN (Print)	9780323755108
DOIs	https://doi.org/10.1016/B978-0-323-67331-0.00002-6
State	Published - Jan 1 2021

Keywords

Abnormal reinnervation syndrome
Hemifacial spasm
Synkinesis

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-323-67331-0.00002-6

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abstract = "The pathological mechanism of synkinesis following facial paralysis is not completely understood. Consequently, current treatment options have mixed efficacy. The main pathophysiologic mechanisms of synkinesis-aberrant regeneration of facial nerve fibers, ephaptic transmission of impulses, and somatotopic reorganization of the facial nucleus- underscores the challenges in establishing effective treatment for synkinesis. More recently, enhanced understanding of the electrophysiologic alterations in peripheral nerves post injury has opened new opportunities for therapeutic targeting and more effective treatment of synkinesis.",

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N2 - The pathological mechanism of synkinesis following facial paralysis is not completely understood. Consequently, current treatment options have mixed efficacy. The main pathophysiologic mechanisms of synkinesis-aberrant regeneration of facial nerve fibers, ephaptic transmission of impulses, and somatotopic reorganization of the facial nucleus- underscores the challenges in establishing effective treatment for synkinesis. More recently, enhanced understanding of the electrophysiologic alterations in peripheral nerves post injury has opened new opportunities for therapeutic targeting and more effective treatment of synkinesis.

AB - The pathological mechanism of synkinesis following facial paralysis is not completely understood. Consequently, current treatment options have mixed efficacy. The main pathophysiologic mechanisms of synkinesis-aberrant regeneration of facial nerve fibers, ephaptic transmission of impulses, and somatotopic reorganization of the facial nucleus- underscores the challenges in establishing effective treatment for synkinesis. More recently, enhanced understanding of the electrophysiologic alterations in peripheral nerves post injury has opened new opportunities for therapeutic targeting and more effective treatment of synkinesis.

KW - Abnormal reinnervation syndrome

KW - Hemifacial spasm

KW - Synkinesis

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M3 - Chapter

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SP - 13

EP - 17

BT - Management of Post-Facial Paralysis Synkinesis

PB - Elsevier

ER -

Etiology, Epidemiology, and Pathophysiology of Post-Facial Paralysis Synkinesis

Abstract

Keywords

ASJC Scopus subject areas

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