Ethylene, an early marker of systemic inflammation in humans

Laurent M. Paardekooper, Geert Van Den Bogaart, Matthijs Kox, Ilse Dingjan, Anne H. Neerincx, Maura B. Bendix, Martin Ter Beest, Frans J.M. Harren, Terence Risby, Peter Pickkers, Nandor Marczin, Simona M. Cristescu

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Ethylene is a major plant hormone mediating developmental processes and stress responses to stimuli such as infection. We show here that ethylene is also produced during systemic inflammation in humans and is released in exhaled breath. Traces of ethylene were detected by laser spectroscopy both in vitro in isolated blood leukocytes exposed to bacterial lipopolysaccharide (LPS) as well as in vivo following LPS administration in healthy volunteers. Exposure to LPS triggers formation of ethylene as a product of lipid peroxidation induced by the respiratory burst. In humans, ethylene was detected prior to the increase of blood levels of inflammatory cytokines and stress-related hormones. Our results highlight that ethylene release is an early and integral component of in vivo lipid peroxidation with important clinical implications as a breath biomarker of bacterial infection.

Original languageEnglish (US)
Article number6889
JournalScientific reports
Issue number1
StatePublished - Dec 1 2017

ASJC Scopus subject areas

  • General


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