Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes

Zhaomeng Cui; Yang Liu; Wei Wan; Yuyan Xu; Yehui Hu; Meng Ding; Xin Dou; Ruina Wang; Hailing Li; Yongmei Meng; Wei Li; Wei Jiang; Zengxia Li; Yiming Li; Minjia Tan; Dengke K. Ma; Yu Ding; Jun O. Liu; Cheng Luo; Biao Yu; Qiqun Tang; Yongjun Dang

doi:10.1007/s13238-020-00717-7

Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes

Zhaomeng Cui, Yang Liu, Wei Wan, Yuyan Xu, Yehui Hu, Meng Ding, Xin Dou, Ruina Wang, Hailing Li, Yongmei Meng, Wei Li, Wei Jiang, Zengxia Li, Yiming Li, Minjia Tan, Dengke K. Ma, Yu Ding, Jun O. Liu, Cheng Luo, Biao YuQiqun Tang, Yongjun Dang

School of Medicine

Research output: Contribution to journal › Letter › peer-review

1 Scopus citations

Original language	English (US)
Pages (from-to)	493-501
Number of pages	9
Journal	Protein and Cell
Volume	12
Issue number	6
DOIs	https://doi.org/10.1007/s13238-020-00717-7
State	Published - Jun 2021

ASJC Scopus subject areas

Biotechnology
Biochemistry
Drug Discovery
Cell Biology

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10.1007/s13238-020-00717-7

Cite this

Cui, Z, Liu, Y, Wan, W, Xu, Y, Hu, Y, Ding, M, Dou, X, Wang, R, Li, H, Meng, Y, Li, W, Jiang, W, Li, Z, Li, Y, Tan, M, Ma, DK, Ding, Y, Liu, JO, Luo, C, Yu, B, Tang, Q & Dang, Y 2021, 'Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes', Protein and Cell, vol. 12, no. 6, pp. 493-501. https://doi.org/10.1007/s13238-020-00717-7

@article{351cd8fc91f5443fbb0bc120f1686aed,

title = "Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes",

author = "Zhaomeng Cui and Yang Liu and Wei Wan and Yuyan Xu and Yehui Hu and Meng Ding and Xin Dou and Ruina Wang and Hailing Li and Yongmei Meng and Wei Li and Wei Jiang and Zengxia Li and Yiming Li and Minjia Tan and Ma, {Dengke K.} and Yu Ding and Liu, {Jun O.} and Cheng Luo and Biao Yu and Qiqun Tang and Yongjun Dang",

note = "Funding Information: Y.D. initiates the project, Y.D., Q.T., B.Y., C.L. and J.L designed and supervised the project; Z.C. and Y.L. did experiments and analyzed and prepared data; W.W., Y.H., J.H., and Y.D. contributed to protein structure and computational calculation. Z.C., Y.L., Y.X., M.D., X.D., and Z.L. performed animal experiments. R.W. and W.L. contributed to the chemical synthesis. The manuscript was written by Z.C., Y.L., and Y.D. All authors read and contributed to the final manuscript. This work was supported by the National Key Research and Development Program of China (No. 2018YFC0310900), the National Natural Science Foundation of China grants (31270830, 21572038 and 21877016 to Y.D 81730021 to Q.-Q.T. 81625022, 91853205 to C.L. and K. C. Wong Education Foundation to C.L.), the National Basic Research Program of China (973 Program) (2014CBA02004 to M.T), the Development Fund for Shanghai Talents, Fund of State Key Laboratory of Bioorganic and Natural Products Chemistry, and Fund of State Key Laboratory of Drug Research, Chinese Academy of Science (SIMM1601KF-08). ",

year = "2021",

month = jun,

doi = "10.1007/s13238-020-00717-7",

language = "English (US)",

volume = "12",

pages = "493--501",

journal = "Protein and Cell",

issn = "1674-800X",

publisher = "Springer-Verlag GmbH and Co. KG",

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TY - JOUR

T1 - Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes

AU - Cui, Zhaomeng

AU - Liu, Yang

AU - Wan, Wei

AU - Xu, Yuyan

AU - Hu, Yehui

AU - Ding, Meng

AU - Dou, Xin

AU - Wang, Ruina

AU - Li, Hailing

AU - Meng, Yongmei

AU - Li, Wei

AU - Jiang, Wei

AU - Li, Zengxia

AU - Li, Yiming

AU - Tan, Minjia

AU - Ma, Dengke K.

AU - Ding, Yu

AU - Liu, Jun O.

AU - Luo, Cheng

AU - Yu, Biao

AU - Tang, Qiqun

AU - Dang, Yongjun

N1 - Funding Information: Y.D. initiates the project, Y.D., Q.T., B.Y., C.L. and J.L designed and supervised the project; Z.C. and Y.L. did experiments and analyzed and prepared data; W.W., Y.H., J.H., and Y.D. contributed to protein structure and computational calculation. Z.C., Y.L., Y.X., M.D., X.D., and Z.L. performed animal experiments. R.W. and W.L. contributed to the chemical synthesis. The manuscript was written by Z.C., Y.L., and Y.D. All authors read and contributed to the final manuscript. This work was supported by the National Key Research and Development Program of China (No. 2018YFC0310900), the National Natural Science Foundation of China grants (31270830, 21572038 and 21877016 to Y.D 81730021 to Q.-Q.T. 81625022, 91853205 to C.L. and K. C. Wong Education Foundation to C.L.), the National Basic Research Program of China (973 Program) (2014CBA02004 to M.T), the Development Fund for Shanghai Talents, Fund of State Key Laboratory of Bioorganic and Natural Products Chemistry, and Fund of State Key Laboratory of Drug Research, Chinese Academy of Science (SIMM1601KF-08).

PY - 2021/6

Y1 - 2021/6

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U2 - 10.1007/s13238-020-00717-7

DO - 10.1007/s13238-020-00717-7

M3 - Letter

C2 - 32399897

AN - SCOPUS:85084610133

SN - 1674-800X

VL - 12

SP - 493

EP - 501

JO - Protein and Cell

JF - Protein and Cell

IS - 6

ER -

Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes

ASJC Scopus subject areas

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