Abstract
Background: Estrogen protects against cardiovascular disease in both patients and animal models and regulates insulin-like growth factor-I (IGF- I), an important cell-cycle progression factor. Methods and Results: Smooth muscle cells and tissues were harvested from male recipient rabbits that 6 weeks earlier had received a cardiac allograft transplant consisting of a donor heart and ascending aorta. Segments of the ascending aorta from the native and allograft hearts from 9 placebo-treated and 8 estradiol-treated recipients were compared by using IGF-I-stimulated [3H]thymidine incorporation. The responses of the native vessel segments were similar (175.3±32% and 166.9±41%, respectively; P>.05) whether or not the recipients had been treated for 6 weeks with estradiol. In the grafts, however, estradiol markedly inhibited vascular cell thymidine incorporation (328.04±56% compared with 67.3±11%; P
Original language | English (US) |
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Pages (from-to) | 927-933 |
Number of pages | 7 |
Journal | Circulation |
Volume | 96 |
Issue number | 3 |
State | Published - Aug 5 1997 |
Externally published | Yes |
Keywords
- Coronary disease
- Hormones
- Immunohistochemistry
- Muscle, smooth
- Transplantation
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine