TY - JOUR
T1 - Estrogen action and cytoplasmic signaling cascades. Part I
T2 - Membrane-associated signaling complexes
AU - Segars, James H.
AU - Driggers, Paul H.
N1 - Funding Information:
We thank George Anderson for his help in the preparation of this review and Domenica Rubino and John Wu for their critical reading of it. P.H.D. is supported, in part, by a grant from the DOD. We also thank George Chrousos and William Haffner for their support and assistance.
PY - 2002/10
Y1 - 2002/10
N2 - Remarkable progress in recent years has suggested that estrogen action in vivo is complex and often involves activation of cytoplasmic signaling cascades in addition to genomic actions mediated directly through estrogen receptors α and β. Rather than a linear response mediated solely through estrogen- responsive DNA elements, in vivo estrogen might simultaneously activate distinct signaling cascades that function as networks to coordinate tissue responses to estrogen. This complex signaling system provides for exquisite control and plasticity of response to estrogen at the tissue level, and undoubtedly contributes to the remarkable tissue-specific responses to estrogens. In part I of this series, we summarize cytoplasmic signaling modules involving estrogen or estrogen receptors, with particular focus on recently described membrane-associated signaling complexes.
AB - Remarkable progress in recent years has suggested that estrogen action in vivo is complex and often involves activation of cytoplasmic signaling cascades in addition to genomic actions mediated directly through estrogen receptors α and β. Rather than a linear response mediated solely through estrogen- responsive DNA elements, in vivo estrogen might simultaneously activate distinct signaling cascades that function as networks to coordinate tissue responses to estrogen. This complex signaling system provides for exquisite control and plasticity of response to estrogen at the tissue level, and undoubtedly contributes to the remarkable tissue-specific responses to estrogens. In part I of this series, we summarize cytoplasmic signaling modules involving estrogen or estrogen receptors, with particular focus on recently described membrane-associated signaling complexes.
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U2 - 10.1016/S1043-2760(02)00633-1
DO - 10.1016/S1043-2760(02)00633-1
M3 - Review article
C2 - 12217492
AN - SCOPUS:0036780306
SN - 1043-2760
VL - 13
SP - 349
EP - 354
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 8
ER -