Abstract
A method is proposed to calculate the maximum likelihood estimate of gene frequency and linkage disequilibrium from disease-codominant marker conditional data. The method is illustrated using data on sickle-cell anemia and Duchenne muscular dystrophy and linked polymorphic restriction endonuclease cleavage sites.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 177-186 |
| Number of pages | 10 |
| Journal | American journal of human genetics |
| Volume | 36 |
| Issue number | 1 |
| State | Published - 1984 |
| Externally published | Yes |
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)