Estimation of spatial variation in risk using matched case-control data

Mikala F. Jarner, Peter J. Diggle, Amanda G. Chetwynd

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


A common problem in environmental epidemiology is to estimate spatial variation in disease risk after accounting for known risk factors. In this paper we consider this problem in the context of matched case-control studies. We extend the generalised additive model approach of KELSALL and DIGGLE (1998) to studies in which each case has been individually matched to a set of controls. We discuss a method for fitting this model to data, apply the method to a matched study on perinatal death in the North West Thames region of England and explain why, if spatial variation is of particular scientific interest, matching is undesirable.

Original languageEnglish (US)
Pages (from-to)936-945
Number of pages10
JournalBiometrical Journal
Issue number8
StatePublished - 2002
Externally publishedYes


  • Epidemiology
  • Generalised additive models
  • Matched case-control design
  • Spatial variation in risk

ASJC Scopus subject areas

  • Statistics and Probability


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