Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: A new approach

Holly B. Posner; Stefan Cano; Maria C. Carrillo; Ola Selnes; Yaakov Stern; Ronald G. Thomas; John Zajicek; Jeremy Hobart

doi:10.1016/j.jalz.2012.10.008

Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: A new approach

Holly B. Posner, Stefan Cano, Maria C. Carrillo, Ola Selnes, Yaakov Stern, Ronald G. Thomas, John Zajicek, Jeremy Hobart

School of Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The Alzheimer's disease (AD) Cognitive Behavior Section (ADAS-Cog) is the most commonly used cognitive test in clinical trials of AD. Recent trials have focused on people earlier in the course of disease; however, there are concerns about using the ADAS-Cog at this crucial stage. Using data from the Alzheimer's disease Neuroimaging Initiative study, we used a range of traditional psychometric tests to evaluate those concerns. This issue of Alzheimer's & Dementia includes two articles that evaluate the ADAS-Cog. These articles report evaluations using two psychometric approaches: traditional methods and new methods. In this review, we provide accompanying background information to this program of research.

Original language	English (US)
Pages (from-to)	S56-S60
Journal	Alzheimer's and Dementia
Volume	9
Issue number	1 SUPPL.
DOIs	https://doi.org/10.1016/j.jalz.2012.10.008
State	Published - Feb 2013

Keywords

ADAS-Cog
ADNI
Alzheimer's disease
Cognition
MCI
Neuropsychology
Psychometric

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health
Cellular and Molecular Neuroscience

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10.1016/j.jalz.2012.10.008

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title = "Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: A new approach",

abstract = "The Alzheimer's disease (AD) Cognitive Behavior Section (ADAS-Cog) is the most commonly used cognitive test in clinical trials of AD. Recent trials have focused on people earlier in the course of disease; however, there are concerns about using the ADAS-Cog at this crucial stage. Using data from the Alzheimer's disease Neuroimaging Initiative study, we used a range of traditional psychometric tests to evaluate those concerns. This issue of Alzheimer's & Dementia includes two articles that evaluate the ADAS-Cog. These articles report evaluations using two psychometric approaches: traditional methods and new methods. In this review, we provide accompanying background information to this program of research.",

keywords = "ADAS-Cog, ADNI, Alzheimer's disease, Cognition, MCI, Neuropsychology, Psychometric",

author = "Posner, {Holly B.} and Stefan Cano and Carrillo, {Maria C.} and Ola Selnes and Yaakov Stern and Thomas, {Ronald G.} and John Zajicek and Jeremy Hobart",

note = "Funding Information: Our overarching goal in this stage of the research was to provide guidance for the potential improvement, in measurement terms, of an existing scale that has been used as the basis of approval in previous clinical trials—in other words, the ADAS-Cog. In particular, we aimed to examine the potential to capture more completely the cognitive performance of people with mild AD and its precursors. We engaged the full range of key stakeholders in this effort, including experts in the fields of AD, neuropsychology, and psychometrics; pharmaceutical companies; and the advocacy community. The project was funded by the Alzheimer's Association and another nonprofit organization. ",

year = "2013",

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AU - Cano, Stefan

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AU - Selnes, Ola

AU - Stern, Yaakov

AU - Thomas, Ronald G.

AU - Zajicek, John

AU - Hobart, Jeremy

N1 - Funding Information: Our overarching goal in this stage of the research was to provide guidance for the potential improvement, in measurement terms, of an existing scale that has been used as the basis of approval in previous clinical trials—in other words, the ADAS-Cog. In particular, we aimed to examine the potential to capture more completely the cognitive performance of people with mild AD and its precursors. We engaged the full range of key stakeholders in this effort, including experts in the fields of AD, neuropsychology, and psychometrics; pharmaceutical companies; and the advocacy community. The project was funded by the Alzheimer's Association and another nonprofit organization.

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Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: A new approach

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Keywords

ASJC Scopus subject areas

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