Erythropoietin Response to Anemia as a Function of Age

James S. Powers; Sanford B. Krantz; Jerry C. Collins; Karen Meurer; Ann Failinger; Terry Buchholz; Michael Blank; Jerry L. Spivak; Mark Hochberg; Alan Baer; P. Mary Cotes; Eugene Goldwasser

doi:10.1111/j.1532-5415.1991.tb05902.x

Erythropoietin Response to Anemia as a Function of Age

James S. Powers, Sanford B. Krantz, Jerry C. Collins, Karen Meurer, Ann Failinger, Terry Buchholz, Michael Blank, Jerry L. Spivak, Mark Hochberg, Alan Baer, P. Mary Cotes, Eugene Goldwasser

School of Medicine

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

The erythropoietin (EPO) response to anemia was assessed for 244 subjects aged 1–64 years (mean 45.2 years) and 121 subjects aged 65–94 years (mean 68.3 years). Subjects included non‐anemic individuals as well as those with anemia of various etiologies, excluding renal disease and pregnancy. Significant inverse correlations between serum immunoreactive EPO and hematocrit were noted for both groups. Regression lines failed to show a significantly lower slope or y‐intercept for older compared to younger subjects. EPO levels were not significantly lower for older compared to younger subjects when controlled for hematocrit level. These results suggest that the EPO response to anemia in older subjects is similar to that of younger subjects. 1991 The American Geriatrics Society

Original language	English (US)
Pages (from-to)	30-32
Number of pages	3
Journal	Journal of the American Geriatrics Society
Volume	39
Issue number	1
DOIs	https://doi.org/10.1111/j.1532-5415.1991.tb05902.x
State	Published - Jan 1991

ASJC Scopus subject areas

Geriatrics and Gerontology

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10.1111/j.1532-5415.1991.tb05902.x

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title = "Erythropoietin Response to Anemia as a Function of Age",

abstract = "The erythropoietin (EPO) response to anemia was assessed for 244 subjects aged 1–64 years (mean 45.2 years) and 121 subjects aged 65–94 years (mean 68.3 years). Subjects included non‐anemic individuals as well as those with anemia of various etiologies, excluding renal disease and pregnancy. Significant inverse correlations between serum immunoreactive EPO and hematocrit were noted for both groups. Regression lines failed to show a significantly lower slope or y‐intercept for older compared to younger subjects. EPO levels were not significantly lower for older compared to younger subjects when controlled for hematocrit level. These results suggest that the EPO response to anemia in older subjects is similar to that of younger subjects. 1991 The American Geriatrics Society",

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AU - Powers, James S.

AU - Krantz, Sanford B.

AU - Collins, Jerry C.

AU - Meurer, Karen

AU - Failinger, Ann

AU - Buchholz, Terry

AU - Blank, Michael

AU - Spivak, Jerry L.

AU - Hochberg, Mark

AU - Baer, Alan

AU - Cotes, P. Mary

AU - Goldwasser, Eugene

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AB - The erythropoietin (EPO) response to anemia was assessed for 244 subjects aged 1–64 years (mean 45.2 years) and 121 subjects aged 65–94 years (mean 68.3 years). Subjects included non‐anemic individuals as well as those with anemia of various etiologies, excluding renal disease and pregnancy. Significant inverse correlations between serum immunoreactive EPO and hematocrit were noted for both groups. Regression lines failed to show a significantly lower slope or y‐intercept for older compared to younger subjects. EPO levels were not significantly lower for older compared to younger subjects when controlled for hematocrit level. These results suggest that the EPO response to anemia in older subjects is similar to that of younger subjects. 1991 The American Geriatrics Society

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Erythropoietin Response to Anemia as a Function of Age

Abstract

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