Erratum: Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis (Proc. Natl. Acad. Sci. U.S.A. (2013) 110 (E1788–E1796) DOI: 10.1073/pnas.1305961110)

Guoxiang Yuan, Ying Jie Peng, Vaddi Damodara Reddy, Vladislav V. Makarenko, Jayasri Nanduri, Shakil A. Khan, Joseph A. Garcia, Ganesh K. Kumar, Gregg L. Semenza, Nanduri R. Prabhakar

Research output: Contribution to journalComment/debatepeer-review

Abstract

The authors note, “We are retracting this article due to concerns with Figure 5. In Figure 5A, there is a concern that the first and second lanes of the HIF-2α panel show the same data, and that the first and second lanes of the HIF-1α panel show the same data, despite all being labeled as unique data. In Figure 5D, there is a concern that the second and third lanes of the HIF-1β panel show the same data despite being labeled as unique data. We believe that the overall conclusions of the paper remain valid, but we are retracting the work due to these underlying concerns about the figure. Confirmatory experimentation has now been performed and the results can be found in a preprint article posted on bioRxiv, ‘Homeostatic responses to hypoxia by the carotid body and adrenal medulla are based on mutual antagonism between HIF-1α and HIF-2α’ (https://doi.org/10.1101/2022.07.11.499380). We apologize for the inconvenience.”

Original languageEnglish (US)
Article numbere2213287119
JournalProceedings of the National Academy of Sciences of the United States of America
Volume119
Issue number38
DOIs
StatePublished - Sep 20 2022

ASJC Scopus subject areas

  • General

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