Erratum: Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques (PLoS Pathogens (2021) 17:5 (e1009565) DOI: 10.1371/journal.ppat.1009565)

Rachele M. Bochart, Kathleen Busman-Sahay, Stephen Bondoc, David W. Morrow, Alexandra M. Ortiz, Christine M. Fennessey, Miranda B. Fischer, Oriene Shiel, Tonya Swanson, Christine M. Shriver-Munsch, Hugh B. Crank, Kimberly M. Armantrout, Aaron M. Barber-Axthelm, Charlotte Langner, Cassandra R. Moats, Caralyn S. Labriola, Rhonda MacAllister, Michael K. Axthelm, Jason M. Brenchley, Brandon F. KeeleJacob D. Estes, Scott G. Hansen, Jeremy V. Smedley

Research output: Contribution to journalComment/debatepeer-review

Abstract

The published article [1] presents data from two separate animal studies. The first study conducted at the National Cancer Institute (NCI) comprised an 18-rhesus macaque (RM) intrarectal dose titration experiment to determine appropriate dosing of SIVmac239X for use in viral transmission/early necropsy studies. This notice addresses errors in the methodological description for the initial NCI study: in these animals, the authors did not assess gastrointestinal pathogens, microbiome, immunology, or mucosal barrier integrity, and the handling and treatment of the animals differed from that employed in the subsequent study conducted at Oregon National Primate Research Center (ONPRC). The originally published Materials and Methods section incorrectly reported some similarities between the animal handling and treatment regimens used in the two studies. This Correction provides amended methodological information, including that the multimodal therapeutic regimen for the NCI study included only metronidazole and fenbendazole, while the regimen for the ONPRC study included enrofloxacin, paromomycin, fenbendazole, and azithromycin.

Original languageEnglish (US)
Article numbere1011343
JournalPLoS pathogens
Volume19
Issue number4
DOIs
StatePublished - Apr 2023

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Virology
  • Parasitology
  • Microbiology
  • Immunology

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