Erratum: Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension (Proceedings of the National Academy of Sciences of the United States of America (2011) 108 (3065-3070) DOI: 10.1073/pnas.1100064108)

Ying Jie Peng, Jayasri Nanduri, Shakil A. Khan, Guoxiang Yuan, Ning Wang, Brian Kinsman, Damodara R. Vaddi, Ganesh K. Kumar, Joseph A. Garcia, Gregg L. Semenza, Nanduri R. Prabhakar

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Correction for “Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension,” by Ying-Jie Peng, Jayasri Nanduri, Shakil A. Khan, Guoxiang Yuan, Ning Wang, Brian Kinsman, Damodara R. Vaddi, Ganesh K. Kumar, Joseph A. Garcia, Gregg L. Semenza, and Nanduri R. Prabhakar, which was first published January 31, 2011; 10.1073/pnas.1100064108 (Proc. Natl. Acad. Sci. U.S.A. 108, 3065-3070). In response to an allegation of a splice in the HIF-2α panel of Fig. 3A, the authors note that: “We were unable to locate the original data shown in Figure 3A. However, we were able to locate an original blot of HIF-2α from a replicate experiment, which demonstrates reduced HIF-2α protein in adrenal medullae of 4 HIF-2α HET mice as compared to adrenal medullae of 3 wild type C57BL6 mice, on which HIF-2α HET mice were raised. Although there might have been splicing in the published blot, we regret not being able to confirm with the original blot. Nonetheless, the replicate blot demonstrated reduced HIF-2α expression in adrenal medullae in HIF-2α HET mice as originally reported in the published manuscript”. (Figure Presented).

Original languageEnglish (US)
Article numbere2210923119
JournalProceedings of the National Academy of Sciences of the United States of America
Volume119
Issue number38
DOIs
StatePublished - Sep 20 2022

ASJC Scopus subject areas

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