TY - JOUR
T1 - Erratum
T2 - Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia (Brain (2020) 143 (234-48) DOI: 10.1093/brain/awz350)
AU - International Parkinson's Disease Genomics Consortium (IPDGC)
AU - 23andMe Research Team
AU - Blauwendraat, Cornelis
AU - Reed, Xylena
AU - Krohn, Lynne
AU - Heilbron, Karl
AU - Bandres-Ciga, Sara
AU - Tan, Manuela
AU - Raphael Gibbs, J.
AU - Hernandez, Dena G.
AU - Kumaran, Ravindran
AU - Langston, Rebekah
AU - Bonet-Ponce, Luis
AU - Alcalay, Roy N.
AU - Hassin-Baer, Sharon
AU - Greenbaum, Lior
AU - Iwaki, Hirotaka
AU - Leonard, Hampton L.
AU - Grenn, Francis P.
AU - Ruskey, Jennifer A.
AU - Sabir, Marya
AU - Ahmed, Sarah
AU - Makarious, Mary B.
AU - Pihlstrøm, Lasse
AU - Toft, Mathias
AU - van Hilten, Jacobus J.
AU - Marinus, Johan
AU - Schulte, Claudia
AU - Brockmann, Kathrin
AU - Sharma, Manu
AU - Siitonen, Ari
AU - Majamaa, Kari
AU - Eerola-Rautio, Johanna
AU - Tienari, Pentti J.
AU - Pantelyat, Alexander
AU - Hillis, Argye E.
AU - Dawson, Ted M.
AU - Rosenthal, Liana S.
AU - Albert, Marilyn S.
AU - Resnick, Susan M.
AU - Ferrucci, Luigi
AU - Morris, Christopher M.
AU - Pletnikova, Olga
AU - Troncoso, Juan
AU - Grosset, Donald
AU - Lesage, Suzanne
AU - Corvol, Jean Christophe
AU - Brice, Alexis
AU - Noyce, Alastair J.
AU - Masliah, Eliezer
AU - Wood, Nick
AU - Hardy, John
N1 - Publisher Copyright:
© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/)
PY - 2020/3/1
Y1 - 2020/3/1
N2 - The authors apologize for an error in the 'Genetic modifiers of age at onset in GBA associated Parkinson's disease cases' section in the Results. The first paragraph should read: Information on age at onset was available for the majority of the IPDGC GBA Parkinson's disease cases [89.9% n = 1353 cases, average = 60.54 years, standard deviation (SD) = 11.42]. Cases with two GBA variants (either homozygous or compound heterozygous, n = 38) had a lower age at onset compared to single variant carriers; however, no statistically significant difference was detected [P = 0.107; linear regression, Beta = -2.93 years, standard error (SE) = 1.82, two GBA variant case average = 56.81, SD = 10.50 versus single GBA variant case average = 60.54, SD = 11.42]. The age at onset of GBA Parkinson's disease cases was significantly lower compared to non-GBA Parkinson's disease cases [linear regression, P = 9.70 * 10-6, Beta = -1.43, SE = 0.324, GBA Parkinson's disease case average (one GBA mutation) = 60.54, SD = 11.42 versus non-GBA case average = 62.06, SD = 12.01]. On average p.N370S cases had the earliest age at onset followed by p.E326K and p.T369M. Of note, the LRRK2 p.G2019S variant was also identified in 14 GBA carriers (nine p.N370S and five p.E326K carriers) and did not seem to influence the age at onset P = 0.44 (linear regression, Beta = 2.41, SE = 3.15, GBA Parkinson's disease LRRK2 p.G2019S carriers average = 63.86, SD = 10.87 versus GBA Parkinson's disease nonLRRK2 p.G2019S average = 60.29, SD = 11.80), which is consistent with previous findings, although power was limited given the small number of included individuals (Yahalom et al., 2019).
AB - The authors apologize for an error in the 'Genetic modifiers of age at onset in GBA associated Parkinson's disease cases' section in the Results. The first paragraph should read: Information on age at onset was available for the majority of the IPDGC GBA Parkinson's disease cases [89.9% n = 1353 cases, average = 60.54 years, standard deviation (SD) = 11.42]. Cases with two GBA variants (either homozygous or compound heterozygous, n = 38) had a lower age at onset compared to single variant carriers; however, no statistically significant difference was detected [P = 0.107; linear regression, Beta = -2.93 years, standard error (SE) = 1.82, two GBA variant case average = 56.81, SD = 10.50 versus single GBA variant case average = 60.54, SD = 11.42]. The age at onset of GBA Parkinson's disease cases was significantly lower compared to non-GBA Parkinson's disease cases [linear regression, P = 9.70 * 10-6, Beta = -1.43, SE = 0.324, GBA Parkinson's disease case average (one GBA mutation) = 60.54, SD = 11.42 versus non-GBA case average = 62.06, SD = 12.01]. On average p.N370S cases had the earliest age at onset followed by p.E326K and p.T369M. Of note, the LRRK2 p.G2019S variant was also identified in 14 GBA carriers (nine p.N370S and five p.E326K carriers) and did not seem to influence the age at onset P = 0.44 (linear regression, Beta = 2.41, SE = 3.15, GBA Parkinson's disease LRRK2 p.G2019S carriers average = 63.86, SD = 10.87 versus GBA Parkinson's disease nonLRRK2 p.G2019S average = 60.29, SD = 11.80), which is consistent with previous findings, although power was limited given the small number of included individuals (Yahalom et al., 2019).
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U2 - 10.1093/brain/awaa036
DO - 10.1093/brain/awaa036
M3 - Comment/debate
C2 - 32091085
AN - SCOPUS:85090417150
SN - 0006-8950
VL - 143
SP - e33
JO - Brain
JF - Brain
IS - 3
ER -