Epstein-Barr virus-associated hepatic smooth muscle neoplasm in a cardiac transplant recipient

Andrew M. Davidoff, Andre Hebra, Bernard J. Clark, John E. Tomaszewski, Kathleen T. Montone, Eduardo Ruchelli, Henry T. Lau

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Host immunosuppression is increasingly recognized as a significant risk factor for the development of a primary neoplasm. Chronic immunosuppressive therapy, as used in organ transplantation, may perturb the immunosurveillance ability of the host, making the patient more susceptible to virus-associated malignancies. We have taken care of a child who received an orthotopic heart transplant and who then developed both a generalized lymphoproliferative disorder and a leiomyoma of the liver a year later. Epstein-Barr virus DNA was detected in a lymph node initially and the hepatic tumor cells subsequently. The former responded to a reduction in the immunosuppressive medications and the latter responded to surgical resection. This is the first report of a hepatic smooth cell neoplasm occurring following cardiac transplant and the development of two sequential Epstein-Barr virus- associated disorders in an immunosuppressed patient.

Original languageEnglish (US)
Pages (from-to)515-517
Number of pages3
Issue number3
StatePublished - Feb 15 1996
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation
  • Immunology


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