Epithelial damage in rabbit corneas exposed to CO2 laser radiation

C. B. Bargeron, O. J. Deters, R. A. Farrell, R. L. McCally

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Corneal injury thresholds are determined for conditions not previously explored for CO2 laser radiation, including multiple-pulse exposures and a systematic investigation of the effect of beam diameter on single-pulse damage thresholds. Multiple-pulse exposures from pulse trains up to 999 pulses, having pulse repetition frequencies between 1 and 100 Hz and individual pulse durations between 10-3 and 0.5 s, were explored. Damage thresholds are discussed in terms of an approximate critical temperature model, the damage integral model and other empirical correlations. Single-pulse exposures are accurately correlated by an empirical critical temperature model in which the critical temperatures have a weak dependence on exposure duration. However, certain aspects of the single-pulse damage data led us to propose a new thermal damage model that incorporates an endothermic phase transition as the damage mechanism. This physical model accurately correlates single-pulse damage for exposures between 10-3 and ~10 s.

Original languageEnglish (US)
Pages (from-to)85-95
Number of pages11
JournalHealth physics
Issue number1
StatePublished - Jan 1989

ASJC Scopus subject areas

  • Epidemiology
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis


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