Episodic secretion of luteinizing and follicle-stimulating hormones in agonadal and hypogonadal adolescents and adults

Allen Root; Allen Decherney; David Russ; Gregory Duckett; Celso Ramon Garcia; Edward Wallach

doi:10.1210/jcem-35-5-700

Episodic secretion of luteinizing and follicle-stimulating hormones in agonadal and hypogonadal adolescents and adults

Allen Root, Allen Decherney, David Russ, Gregory Duckett, Celso Ramon Garcia, Edward Wallach

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Serum concentrations of luteinizing hormone (LH) and follicle stimulating hormone (FSH) were determined in specimens obtained sequentially at IS- or 20-min intervals for six- or eight-hr periods in: girls of adolescent age with gonadal dysgenesis (N-4); ovariectomized adult females (N-5); a post-menopausal woman; agonadal young adult males (N-2); and one subject with Klinefelter’s syndrome. LH levels oscillated significantly in each of these patients. FSH concentrations also varied in the majority of subjects, although the oscillations were not as marked as those of LH. FSH and LH fluctuations were often, but not always, synchronous. It is suggested that the rhythmic oscillations in peripheral gonadotropin levels reflect intermittent stimulation of pituitary secretion by the hypothalamic gonadotropin releasing hormone(s).

Original language	English (US)
Pages (from-to)	700-704
Number of pages	5
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	35
Issue number	5
DOIs	https://doi.org/10.1210/jcem-35-5-700
State	Published - 1972
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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10.1210/jcem-35-5-700

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abstract = "Serum concentrations of luteinizing hormone (LH) and follicle stimulating hormone (FSH) were determined in specimens obtained sequentially at IS- or 20-min intervals for six- or eight-hr periods in: girls of adolescent age with gonadal dysgenesis (N-4); ovariectomized adult females (N-5); a post-menopausal woman; agonadal young adult males (N-2); and one subject with Klinefelter{\textquoteright}s syndrome. LH levels oscillated significantly in each of these patients. FSH concentrations also varied in the majority of subjects, although the oscillations were not as marked as those of LH. FSH and LH fluctuations were often, but not always, synchronous. It is suggested that the rhythmic oscillations in peripheral gonadotropin levels reflect intermittent stimulation of pituitary secretion by the hypothalamic gonadotropin releasing hormone(s).",

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AU - Root, Allen

AU - Decherney, Allen

AU - Russ, David

AU - Duckett, Gregory

AU - Garcia, Celso Ramon

AU - Wallach, Edward

PY - 1972

Y1 - 1972

N2 - Serum concentrations of luteinizing hormone (LH) and follicle stimulating hormone (FSH) were determined in specimens obtained sequentially at IS- or 20-min intervals for six- or eight-hr periods in: girls of adolescent age with gonadal dysgenesis (N-4); ovariectomized adult females (N-5); a post-menopausal woman; agonadal young adult males (N-2); and one subject with Klinefelter’s syndrome. LH levels oscillated significantly in each of these patients. FSH concentrations also varied in the majority of subjects, although the oscillations were not as marked as those of LH. FSH and LH fluctuations were often, but not always, synchronous. It is suggested that the rhythmic oscillations in peripheral gonadotropin levels reflect intermittent stimulation of pituitary secretion by the hypothalamic gonadotropin releasing hormone(s).

AB - Serum concentrations of luteinizing hormone (LH) and follicle stimulating hormone (FSH) were determined in specimens obtained sequentially at IS- or 20-min intervals for six- or eight-hr periods in: girls of adolescent age with gonadal dysgenesis (N-4); ovariectomized adult females (N-5); a post-menopausal woman; agonadal young adult males (N-2); and one subject with Klinefelter’s syndrome. LH levels oscillated significantly in each of these patients. FSH concentrations also varied in the majority of subjects, although the oscillations were not as marked as those of LH. FSH and LH fluctuations were often, but not always, synchronous. It is suggested that the rhythmic oscillations in peripheral gonadotropin levels reflect intermittent stimulation of pituitary secretion by the hypothalamic gonadotropin releasing hormone(s).

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Episodic secretion of luteinizing and follicle-stimulating hormones in agonadal and hypogonadal adolescents and adults

Abstract

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