Epilepsy in Down syndrome: Clinical aspects and possible mechanisms

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations


Although epilepsy is more common in persons with trisomy 21 (Down syndrome) than in the general population, the mechanisms by which seizures are generated in this population have received little attention. It is likely that this increased seizure susceptibility is due to a combination of medical risk factors and inherent neurologic abnormalities characteristic of Down syndrome. In this review clinical aspects of seizures among individuals with Down syndrome were described and possible mechanisms by which the trisomy 21 brain may generate seizures were explored.

Original languageEnglish (US)
Pages (from-to)12-26
Number of pages15
JournalAmerican Journal on Mental Retardation
Issue numberSUPPL.
StatePublished - Jan 1 1993
Externally publishedYes

ASJC Scopus subject areas

  • Education
  • Rehabilitation
  • Developmental and Educational Psychology
  • General Health Professions


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