@article{6e11858b7bd84b63a33da312b51b7aab,
title = "Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis",
abstract = "Fan et al. demonstrate that ovarian cancer reprograms the epigenome of stromal cells, inducing a mesenchymal-to-epithelial transition (MET) to form carcinoma-associated mesenchymal stem cells (CA-MSCs). This MET, mediated by WT1 and EZH2, enables CA-MSC:cancer cell co-metastasis. EZH2 inhibition decreases CA-MSC-mediated metastasis, presenting a potential therapeutic opportunity in ovarian cancer.",
keywords = "EZH2, WT1, carcinoma-associated mesenchymal stem cells, epigenomic reprogramming, mesenchymal-to-epithelial transition, metastasis, ovarian cancer, tumor microenvironment",
author = "Huihui Fan and Atiya, {Huda I.} and Yeh Wang and Pisanic, {Thomas R.} and Wang, {Tza Huei} and Shih, {Ie Ming} and Foy, {Kelly K.} and Leonard Frisbie and Buckanovich, {Ronald J.} and Chomiak, {Alison A.} and Tiedemann, {Rochelle L.} and Rothbart, {Scott B.} and Chelsea Chandler and Hui Shen and Coffman, {Lan G.}",
note = "Funding Information: We thank Marie Adams and the Van Andel Institute Genomics Core for DNA methylation microarray and ChIP-seq service and the VAI High Performance Computing Cluster supported by Zack Ramjan. L.G.C. is supported by NIH/NCI grant 7K08CA211362-02; a Tina{\textquoteright}s Wish Rising Star grant; a Mary Kay Foundation Cancer Research grant; and a DoD Ovarian Cancer, Omics Consortium Development Award. H.S. is supported by NIH/NCI grant 1R37CA230748 and Ovarian Cancer Research Alliance {\textquoteright}s Liz Tilberis award ( 373933 ). S.B.R. is supported by NIH grant R35GM124736 . A.A.C. is supported by NIH grant F32CA225043 . R.L.T. is supported by the American Cancer Society–Michigan Cancer Research Fund ( PF-16-245-01-DMC ). Funding Information: We thank Marie Adams and the Van Andel Institute Genomics Core for DNA methylation microarray and ChIP-seq service and the VAI High Performance Computing Cluster supported by Zack Ramjan. L.G.C. is supported by NIH/NCI grant 7K08CA211362-02; a Tina's Wish Rising Star grant; a Mary Kay Foundation Cancer Research grant; and a DoD Ovarian Cancer, Omics Consortium Development Award. H.S. is supported by NIH/NCI grant 1R37CA230748 and Ovarian Cancer Research Alliance's Liz Tilberis award (373933). S.B.R. is supported by NIH grant R35GM124736. A.A.C. is supported by NIH grant F32CA225043. R.L.T. is supported by the American Cancer Society?Michigan Cancer Research Fund (PF-16-245-01-DMC). Conceptualization, L.G.C. and H.S.; Methodology, L.G.C. H.S. H.F. L.F. C.C. T.R.P. Y.W. R.L.T. A.A.C. and S.B.R.; Formal Analysis, L.G.C. H.S. and H.F.; Investigation, L.G.C. L.F. C.C. H.F. H.I.A. R.B. R.L.T. A.A.C. and S.B.R.; Writing ? Original Draft, L.G.C. and H.S.; Writing ? Review & Editing, L.G.C. H.S. H.F. T.R.P. H.I.A. and R.B.; Funding Acquisition, L.G.C. H.S. I.-M.S. and T.-H.W.; Resources, L.G.C. H.S. T.R.P. I.-M.S. T.-H.W. and S.B.R.; Supervision, L.G.C. H.S. I.-M.S. T.-H.W. and S.B.R. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = dec,
day = "8",
doi = "10.1016/j.celrep.2020.108473",
language = "English (US)",
volume = "33",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "10",
}