Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?

Zsolt Czimmerer, Laszlo Nagy

Research output: Contribution to journalReview articlepeer-review

Abstract

Our laboratory has a long-standing research interest in understanding how lipid-activated transcription factors, nuclear hormone receptors, contribute to dendritic cell and macrophage gene expression regulation, subtype specification, and responses to a changing extra and intracellular milieu. This journey in the last more than two decades took us from identifying target genes for various RXR heterodimers to systematically mapping nuclear receptor-mediated pathways in dendritic cells to identifying hierarchies of transcription factors in alternative polarization in macrophages to broaden the role of nuclear receptors beyond strictly ligand-regulated gene expression. We detail here the milestones of the road traveled and draw conclusions regarding the unexpectedly broad role of nuclear hormone receptors as epigenomic components of dendritic cell and macrophage gene regulation as we are getting ready for the next challenges.

Original languageEnglish (US)
Pages (from-to)152-165
Number of pages14
JournalImmunological reviews
Volume317
Issue number1
DOIs
StatePublished - Aug 2023

Keywords

  • EGR2
  • IL-4
  • PPARγ
  • STAT6
  • epigenome
  • macrophage
  • nuclear receptors
  • polarization
  • transcriptional regulation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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