Abstract
Aim: To investigate the role of epigenetics in HIV pathophysiology. Materials & methods: We conducted an epigenome-wide association scan on HIV infection status among people who inject drugs in the AIDS Linked to the IntraVenous Experience study with primary (n = 397) and validation samples (n = 390). DNA methylation from blood was measured by the Illumina EPIC BeadChip. We controlled for cell type heterogeneity by HIV status. Results: HIV infection status was associated (p < 10-8) with DNA methylation at 49 CpG sites. Sites were enriched in response to virus, interferon signaling pathway, etc. Among these sites, discovery and validation t-statistics were highly correlated (r = 0.96). Conclusion: In a cohort of people who inject drugs, HIV status was associated with differential DNA methylation at biologically meaningful sites.
Original language | English (US) |
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Pages (from-to) | 1917-1927 |
Number of pages | 11 |
Journal | Epigenomics |
Volume | 12 |
Issue number | 21 |
DOIs | |
State | Published - Nov 2020 |
Keywords
- DNA methylation
- HIV
- epigenetics
- epigenome-wide association
- people who inject drugs
ASJC Scopus subject areas
- Genetics
- Cancer Research