Epigenetic features that regulate IgH locus recombination and expression

Ramesh Subrahmanyam, Ranjan Sen

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations


Precisely regulated rearrangements that yield imprecise recombination junctions are hallmarks of antigen receptor gene assembly. At the immunoglobulin heavy chain (IgH) gene locus this is initiated by rearrangement of a D H gene segment to a J H gene segment to generate DJ H junctions, followed by rearrangement of a V H gene segment to the DJ H junction to generate fully recombined VDJ alleles. In this review we discuss the regulatory features of each step of IgH gene assembly and the role of epigenetic mechanisms in achieving regulatory precision.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Microbiology and Immunology
Number of pages25
StatePublished - 2012
Externally publishedYes

Publication series

NameCurrent Topics in Microbiology and Immunology
ISSN (Print)0070217X

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology
  • Microbiology


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