Epigenetic alterations in pancreatic cancer

Michael Ayars; Michael Goggins

doi:10.1007/978-1-4614-6549-2_9

Epigenetic alterations in pancreatic cancer

Michael Ayars, Michael Goggins

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Pancreatic cancer remains one of the deadliest malignancies. In addition to genetic alterations a wide variety of epigenetic aberrations have been identified in pancreatic neoplasms some of which are thought to play an important role in neoplastic development and maintenance. Newer technologies are helping to better characterize cancer epigenomes. Efforts are underway to identify epigenetic alterations that would make optimal diagnostic markers and therapeutic targets. In this chapter, we discuss recent findings in the field of pancreatic cancer epigenetics and the implications they hold for future research.

Original language	English (US)
Title of host publication	Molecular Genetics of Pancreatic Cancer
Publisher	Springer New York
Pages	185-207
Number of pages	23
Volume	9781461465492
ISBN (Electronic)	9781461465492
ISBN (Print)	1461465486, 9781461465485
DOIs	https://doi.org/10.1007/978-1-4614-6549-2_9
State	Published - Jan 1 2013

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-1-4614-6549-2_9

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AB - Pancreatic cancer remains one of the deadliest malignancies. In addition to genetic alterations a wide variety of epigenetic aberrations have been identified in pancreatic neoplasms some of which are thought to play an important role in neoplastic development and maintenance. Newer technologies are helping to better characterize cancer epigenomes. Efforts are underway to identify epigenetic alterations that would make optimal diagnostic markers and therapeutic targets. In this chapter, we discuss recent findings in the field of pancreatic cancer epigenetics and the implications they hold for future research.

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Epigenetic alterations in pancreatic cancer

Abstract

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