Epigenetic Abnormalities in Cancer Find a " Home on the Range"

Hariharan Easwaran; Stephen B. Baylin

doi:10.1016/j.ccr.2012.12.018

Epigenetic Abnormalities in Cancer Find a " Home on the Range"

Hariharan Easwaran, Stephen B. Baylin

School of Medicine

Research output: Contribution to journal › Short survey › peer-review

13 Scopus citations

Abstract

Recent studies have highlighted large genomic regions prone to undergo epigenetic changes in cancers. In this issue of Cancer Cell, Bert and colleagues describe novel genomic domains with aberrant epigenetic changes involving concordant activation of neighboring genes. These domains involve aberrant CpG-island hypermethylation similar to that observed in gene silencing.

Original language	English (US)
Pages (from-to)	1-3
Number of pages	3
Journal	Cancer cell
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.ccr.2012.12.018
State	Published - Jan 14 2013

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

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10.1016/j.ccr.2012.12.018

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abstract = "Recent studies have highlighted large genomic regions prone to undergo epigenetic changes in cancers. In this issue of Cancer Cell, Bert and colleagues describe novel genomic domains with aberrant epigenetic changes involving concordant activation of neighboring genes. These domains involve aberrant CpG-island hypermethylation similar to that observed in gene silencing.",

author = "Hariharan Easwaran and Baylin, {Stephen B.}",

note = "Funding Information: Portions of the authors work cited in this article were supported by ES011858 from the National Institutes of Environmental Health Sciences (NIEHS), CA043318 from the National Cancer Institute (NCI), and the Hodson Junior Scholarship Award.",

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N1 - Funding Information: Portions of the authors work cited in this article were supported by ES011858 from the National Institutes of Environmental Health Sciences (NIEHS), CA043318 from the National Cancer Institute (NCI), and the Hodson Junior Scholarship Award.

PY - 2013/1/14

Y1 - 2013/1/14

N2 - Recent studies have highlighted large genomic regions prone to undergo epigenetic changes in cancers. In this issue of Cancer Cell, Bert and colleagues describe novel genomic domains with aberrant epigenetic changes involving concordant activation of neighboring genes. These domains involve aberrant CpG-island hypermethylation similar to that observed in gene silencing.

AB - Recent studies have highlighted large genomic regions prone to undergo epigenetic changes in cancers. In this issue of Cancer Cell, Bert and colleagues describe novel genomic domains with aberrant epigenetic changes involving concordant activation of neighboring genes. These domains involve aberrant CpG-island hypermethylation similar to that observed in gene silencing.

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Epigenetic Abnormalities in Cancer Find a " Home on the Range"

Abstract

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