Epigallocatechin-3-gallate enhances CD8+ T cell-mediated antitumor immunity induced by DNA vaccination

Heung Kang Tae, Hyup Lee Jin, Kil Song Chung, Dong Han Hee, Cheol Shin Byung, Sara I. Pai, Chien Fu Hung, Cornelia Trimble, Jong Seok Lim, Woo Kim Tae, T. C. Wu

Research output: Contribution to journalArticlepeer-review

93 Scopus citations


Immunotherapy and chemotherapy are generally effective against small tumors in animal models of cancer. However, these treatment regimens are generally ineffective against large, bulky tumors. We have found that a multimodality treatment regimen using DNA vaccination in combination with chemotherapeutic agent epigallocatechin-3-gallate (EGCG), a compound found in green tea, is effective in inhibiting large tumor growth. EGCG was found to induce tumor cellular apoptosis in a dose-dependent manner. The combination of EGCG and DNA vaccination led to an enhanced tumor-specific T-cell immune response and enhanced antitumor effects, resulting in a higher cure rate than either immunotherapy or EGCG alone. In addition, combined DNA vaccination and oral EGCG treatment provided long-term antitumor protection in cured mice. Cured animals rejected a challenge of E7-expressing tumors, such as TC-1 and B16E7, but not a challenge of B16 7 weeks after the combined treatment, showing antigen-specific immune responses. These results suggest that multimodality treatment strategies, such as combining immunotherapy with a tumor-killing cancer drug, may be a more effective anticancer strategy than single-modality treatments.

Original languageEnglish (US)
Pages (from-to)802-811
Number of pages10
JournalCancer Research
Issue number2
StatePublished - Jan 15 2007

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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