Epidemiology, diagnosis, and treatment of Hymenoptera venom allergy in mastocytosis patients

Marek Niedoszytko, Patrizia Bonadonna, Joanne N.G.Oude Elberink, David B.K. Golden

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations


Hymenoptera venom allergy is a typical IgE-mediated reaction caused by sensitization to 1 or more allergens of the venom, and accounts for 1.5% to 34% of all cases of anaphylaxis. Patients suffering from mastocytosis are more susceptible to the anaphylactic reactions to an insect sting. This article aims to answer the most important clinical questions raised by the diagnosis and treatment of insect venom allergy in mastocytosis patients. Total avoidance of Hymenoptera is not feasible, and there is no preventive pharmacologic treatment available, although venom immunotherapy reduces the risk of subsequent systemic reactions.

Original languageEnglish (US)
Pages (from-to)365-381
Number of pages17
JournalImmunology and Allergy Clinics of North America
Issue number2
StatePublished - May 2014


  • Hymenoptera venom allergy
  • Immunoglobulin E serology
  • Mastocytosis
  • Venom immunotherapy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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