Epidemiologic differences among serotypes of Cryptococcus neoformans

John E. Bennett, K. J. Kwon-Chung, Dexter H. Howard

Research output: Contribution to journalArticlepeer-review

141 Scopus citations


In the USA, the most prevalent serotype of the fungus, Cryptococcus neoformans, was serotype A. This serotype constituted 203 of 272 isolates from infections and 85 of 89 isolates from the environment. Serotype B or C isolates were infrequent causes of infection, except in Southern California, and were not isolated at all from environmental sources. In Southern California, the absence of serotypes B and C in 67 soil and pigeon dropping isolates was striking, considering that 25 of 49 isolates from infections were serotypes B or C. The site in nature where serotypes B and C exist is currently unknown but differs from that of serotypes A and D. Serotype D may be unusually prevalent in both environmental and patient isolates from Denmark and Italy. Of 24 isolates from those countries, 21 were serotype D.

Original languageEnglish (US)
Pages (from-to)582-586
Number of pages5
JournalAmerican journal of epidemiology
Issue number6
StatePublished - Jun 1977


  • Cryptococcus neoformans
  • Pigeons
  • Serotyping

ASJC Scopus subject areas

  • Epidemiology


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