TY - JOUR
T1 - Epidemic keratoconjunctivitis
T2 - a community outbreak of mixed adenovirus type 8 and type 19 infection
AU - Guyer, B.
AU - O'Day, D. M.
AU - Hierholzer, J. C.
AU - Schaffner, W.
N1 - Funding Information:
Received for publication October 15, 1974, and in revised form March 5, 1975. This study was supported in part by grants no. AI-03082, EY-00344, and EY-00055 from the U.S. Public Health Service and by a grant from Research to Prevent Blindness, Inc. We would like to thank Dr. Robert H. Hutcheson, Jr. (State Epidemiologist), Mr. Carlos Reyes, and Ms. Ella Vander Horst of the Tennessee Department of Public Health; Dr. Roy M. Money; the members of the Nashville Academy of Ophthalmology; Dr. Joseph M. Bistowich, Director of the Metropolitan Nashville Health Department; -Ms. Susan Bigham and Dr. Keith J. Rosing of the Vanderbilt University Hospital; Mr. J. Virgil Peavy for statistical assistance; and Ms. Katharine Hilliard of the Respiratory Virology Section, Center for Disease Control. Please address requests for reprints to Dr. Bernard Guyer, Bureau of Epidemiology, Center for Disease Control, Atlanta, Georgia 30333.
PY - 1975
Y1 - 1975
N2 - During the fall and winter of 1973, 145 cases of epidemic keratoconjunctivitis were diagnosed in Nashville, Tennessee. Of the 74 cases studied virologically and/or serologically, 62% were caused by adenovirus type 8, and 28% were caused by adenovirus 19. Whereas adenovirus type 8 was isolated only from conjunctival scrapings, adenovirus type 19 was isolated from nose and throat swabs as well as from conjunctivae. The two viruses produced clinically indistinguishable eye disease and household secondary attack rates that were not statistically different. Regardless of etiology, the secondary attack rate in households was significantly higher among the contacts of those patients who had severe disease for >28 days than among the contacts of patients who had milder disease of shorter duration.
AB - During the fall and winter of 1973, 145 cases of epidemic keratoconjunctivitis were diagnosed in Nashville, Tennessee. Of the 74 cases studied virologically and/or serologically, 62% were caused by adenovirus type 8, and 28% were caused by adenovirus 19. Whereas adenovirus type 8 was isolated only from conjunctival scrapings, adenovirus type 19 was isolated from nose and throat swabs as well as from conjunctivae. The two viruses produced clinically indistinguishable eye disease and household secondary attack rates that were not statistically different. Regardless of etiology, the secondary attack rate in households was significantly higher among the contacts of those patients who had severe disease for >28 days than among the contacts of patients who had milder disease of shorter duration.
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U2 - 10.1093/infdis/132.2.142
DO - 10.1093/infdis/132.2.142
M3 - Article
C2 - 1159321
AN - SCOPUS:0016758644
SN - 0022-1899
VL - 132
SP - 142
EP - 150
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -