Enzyme-instructed molecular self-assembly confers nanofibers and a supramolecular hydrogel of taxol derivative

Yuan Gao; Yi Kuang; Zu Feng Guo; Zhihong Guo; Isaac J. Krauss; Bing Xu

doi:10.1021/ja904411z

Enzyme-instructed molecular self-assembly confers nanofibers and a supramolecular hydrogel of taxol derivative

Yuan Gao
, Yi Kuang
, Zu Feng Guo
, Zhihong Guo
, Isaac J. Krauss
, Bing Xu

Research output: Contribution to journal › Article › peer-review

299 Scopus citations

Abstract

(Figure Presented) By covalently connecting taxol with a motif that is prone to self-assemble, we successfully generate the precursor (5a), the hydrogelator (5b), and hydrogel of a taxol derivative without compromising the cytotoxic activity of the taxol. This approach promises a general method to create nanofibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself.

Original language	English (US)
Pages (from-to)	13576-13577
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	131
Issue number	38
DOIs	https://doi.org/10.1021/ja904411z
State	Published - Jan 1 2009
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

Access to Document

10.1021/ja904411z

Cite this

@article{5ab3dc10f762452f88397efcc1c35bd9,

title = "Enzyme-instructed molecular self-assembly confers nanofibers and a supramolecular hydrogel of taxol derivative",

abstract = "(Figure Presented) By covalently connecting taxol with a motif that is prone to self-assemble, we successfully generate the precursor (5a), the hydrogelator (5b), and hydrogel of a taxol derivative without compromising the cytotoxic activity of the taxol. This approach promises a general method to create nanofibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself.",

author = "Yuan Gao and Yi Kuang and Guo, \{Zu Feng\} and Zhihong Guo and Krauss, \{Isaac J.\} and Bing Xu",

year = "2009",

month = jan,

day = "1",

doi = "10.1021/ja904411z",

language = "English (US)",

volume = "131",

pages = "13576--13577",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "38",

}

TY - JOUR

T1 - Enzyme-instructed molecular self-assembly confers nanofibers and a supramolecular hydrogel of taxol derivative

AU - Gao, Yuan

AU - Kuang, Yi

AU - Guo, Zu Feng

AU - Guo, Zhihong

AU - Krauss, Isaac J.

AU - Xu, Bing

PY - 2009/1/1

Y1 - 2009/1/1

N2 - (Figure Presented) By covalently connecting taxol with a motif that is prone to self-assemble, we successfully generate the precursor (5a), the hydrogelator (5b), and hydrogel of a taxol derivative without compromising the cytotoxic activity of the taxol. This approach promises a general method to create nanofibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself.

AB - (Figure Presented) By covalently connecting taxol with a motif that is prone to self-assemble, we successfully generate the precursor (5a), the hydrogelator (5b), and hydrogel of a taxol derivative without compromising the cytotoxic activity of the taxol. This approach promises a general method to create nanofibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself.

UR - https://www.scopus.com/pages/publications/70349756884

UR - https://www.scopus.com/pages/publications/70349756884#tab=citedBy

U2 - 10.1021/ja904411z

DO - 10.1021/ja904411z

M3 - Article

C2 - 19731909

AN - SCOPUS:70349756884

SN - 0002-7863

VL - 131

SP - 13576

EP - 13577

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 38

ER -

Enzyme-instructed molecular self-assembly confers nanofibers and a supramolecular hydrogel of taxol derivative

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this