@article{6e1babc869d740be8ed9ed77b1b7ef33,
title = "Enzyme alterable alkylating agents. XI. Clinical trials of an esterase-susceptible water-soluble agent (S-73) for regional chemotherapy",
abstract = "Clinical trials of a new water-soluble short half-life alkylating agent (S-73) administered by intra-arterial infusion into 56 patients with a variety of malignant tumors, revealed only limited usefulness. The best responses were seen in a case of Kaposi's sarcoma, a squamous cell carcinoma of the tongue, an epidermoid carcinoma of the cervix, and metastatic carcinoid to liver. In all, there were 5 good responses, 3 fair responses, 36 with no response, and 12 indeterminates. Further modifications in design and structure of S-73 are in progress to probe for greater tumor specificity.",
author = "Daniel Bakal and Goodman, {Louis E.} and Adolph Ulfohn and Mamaril, {Anselmo G.} and Caplan, {Yale H.} and Simon Calle and Bhagavan, {Belur S.} and Benjamin Witten and Williamson, {Charles E.} and Samuel Sass and Seligman, {Arnold M.}",
note = "Funding Information: From the Departments of Surgery, Sinai Hospital of Baltimore, Inc.. and The Johns Hopkins University School of Medicine, Baltimore, Maryland and Chemical Research Laboratory, Edglvood Arsenal. Maryland. This work xas supported by Research Grant CA-02478 from t.he National Cancer Institute, National Institutes of Health, U.S. Public Health Service, Bethesda, Maryland. Submitted for publication November 8. 1970.",
year = "1971",
month = may,
doi = "10.1016/0022-4804(71)90024-2",
language = "English (US)",
volume = "11",
pages = "217--223",
journal = "Journal of Surgical Research",
issn = "0022-4804",
publisher = "Academic Press Inc.",
number = "5",
}