Envelope gene sequences of human T-lymphotropic virus type I in Taiwan

M. T. Lin, Y. C. Chen, P. J. Chen, Y. C. Yang, J. L. Tang, J. M. Wu, S. E. Chuang, C. S. Yang

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Three major types of HTLV-I had been proposed, the Melanesian type, the Zairian type, and the cosmopolitan type, which was further divided into subtypes A, B and C, according to the phylogenetic tree constructed from LTR sequences of current HLTV-I isolates. In this study, the envelope gene sequences of HTLV-I from 9 Taiwanese were analyzed. Based on the phylogenetic tree constructed by unweighed pair group method and the sequence homology analysis by GCG computer programs, the envelope gene sequences of HTLV-I proviruses from these 9 Taiwanese belonged to subtype A or subtype B of the cosmopolitan type and were closely related to HTLV-I from Japan. Twelve subtype-specific nucleotide variations were deduced from the comparison of complete or partial envelope gene sequences of 16 HTLV-I isolates of known subtypes as well as those of 9 Taiwanese. These data provided the basis for subtyping the cosmopolitan type of HTLV-I by amplification of envelope gene sequences and restriction fragment length polymorphism studies. A more extensive survey based upon this proposal was warranted.

Original languageEnglish (US)
Pages (from-to)219-229
Number of pages11
JournalArchives of Virology
Issue number2
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Virology


Dive into the research topics of 'Envelope gene sequences of human T-lymphotropic virus type I in Taiwan'. Together they form a unique fingerprint.

Cite this