Entropy in biological binding processes: Estimation of translational entropy loss

Kenneth P. Murphy, Dong Xie, Kelly S. Thompson, L. Mario Amzel, Ernesto Freire

Research output: Contribution to journalArticlepeer-review

156 Scopus citations


The loss of translational degrees of freedom makes an important, unfavorable contribution to the free energy of binding. Examination of experimental values suggest that calculation of this entropy using the Sackur–Tetrode equation produces largely overestimated values. Better agreement is obtained using the cratic entropy. Theoretical considerations suggest that the volumes available for the movement of a ligand in solution and in a complex are rather similar, suggesting also that the cratic entropy provides the best estimate of the loss of translational entropy. © 1994 John Wiley & Sons, Inc.

Original languageEnglish (US)
Pages (from-to)63-67
Number of pages5
JournalProteins: Structure, Function, and Bioinformatics
Issue number1
StatePublished - Jan 1994


  • binding energetics
  • entropy
  • macromolecular interactions
  • thermodynamics
  • translational entropy

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology


Dive into the research topics of 'Entropy in biological binding processes: Estimation of translational entropy loss'. Together they form a unique fingerprint.

Cite this