TY - JOUR
T1 - Enteroaggregative escherichia coli may be a new pathogen causing acute and persistent diarrhea
AU - Bhatnagar, Shinjini
AU - Bhan, Maharaj K.
AU - Sommerfelt, Halvor
AU - Sazawal, Sunil
AU - Kumar, Ramesh
AU - Saini, Savita
N1 - Funding Information:
The study was supported financially by the Department of Biotechnology, Government of India, the Norwegian Research Council for Science and the Humanities (grant 334.91/008) and the Norwegian Ministry of Development Cooperation (Ind-040.402).
PY - 1993
Y1 - 1993
N2 - The role of Hep-2 cell adherent Escherichia coli (EAEC) of localized (EAEC-L), diffuse (EAEC-D) and aggregative (EAggEC) phenotype, was investigated in 254 children aged < 48 months seeking treatment for non-bloody diarrhea at an outpatient clinic, and in 107 agematched controls. The stool excretion rates of single isolates from patients/controls for the different phenotypes of Hep-2 cell adherent E. coli were: EAEC-L, 5.9/2.8% p = 0.33; EAEC-D, 7.5/12.1% p = 0.22; and EAggEC, 11.8/3.7% p = 0.03. When patients were categorized by pre-admission diarrheal duration ≥ 14< 14 days, the excretion rates were EAEC-L, 0/7.1% EAEC-D, 9.5/7.1% and EAggEC, 21.4/9.9% the difference approaching significance only for EAggEC (p = 0.06). These findings suggest that EAggEC may be an important cause of diarrhea in children, with a predilection to cause prolonged disease.
AB - The role of Hep-2 cell adherent Escherichia coli (EAEC) of localized (EAEC-L), diffuse (EAEC-D) and aggregative (EAggEC) phenotype, was investigated in 254 children aged < 48 months seeking treatment for non-bloody diarrhea at an outpatient clinic, and in 107 agematched controls. The stool excretion rates of single isolates from patients/controls for the different phenotypes of Hep-2 cell adherent E. coli were: EAEC-L, 5.9/2.8% p = 0.33; EAEC-D, 7.5/12.1% p = 0.22; and EAggEC, 11.8/3.7% p = 0.03. When patients were categorized by pre-admission diarrheal duration ≥ 14< 14 days, the excretion rates were EAEC-L, 0/7.1% EAEC-D, 9.5/7.1% and EAggEC, 21.4/9.9% the difference approaching significance only for EAggEC (p = 0.06). These findings suggest that EAggEC may be an important cause of diarrhea in children, with a predilection to cause prolonged disease.
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U2 - 10.3109/00365549309008546
DO - 10.3109/00365549309008546
M3 - Article
C2 - 8284642
AN - SCOPUS:0027375592
SN - 0036-5548
VL - 25
SP - 579
EP - 583
JO - Scandinavian Journal of Infectious Diseases
JF - Scandinavian Journal of Infectious Diseases
IS - 5
ER -