Enteroaggregative escherichia coli may be a new pathogen causing acute and persistent diarrhea

Shinjini Bhatnagar, Maharaj K. Bhan, Halvor Sommerfelt, Sunil Sazawal, Ramesh Kumar, Savita Saini

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


The role of Hep-2 cell adherent Escherichia coli (EAEC) of localized (EAEC-L), diffuse (EAEC-D) and aggregative (EAggEC) phenotype, was investigated in 254 children aged < 48 months seeking treatment for non-bloody diarrhea at an outpatient clinic, and in 107 agematched controls. The stool excretion rates of single isolates from patients/controls for the different phenotypes of Hep-2 cell adherent E. coli were: EAEC-L, 5.9/2.8% p = 0.33; EAEC-D, 7.5/12.1% p = 0.22; and EAggEC, 11.8/3.7% p = 0.03. When patients were categorized by pre-admission diarrheal duration ≥ 14< 14 days, the excretion rates were EAEC-L, 0/7.1% EAEC-D, 9.5/7.1% and EAggEC, 21.4/9.9% the difference approaching significance only for EAggEC (p = 0.06). These findings suggest that EAggEC may be an important cause of diarrhea in children, with a predilection to cause prolonged disease.

Original languageEnglish (US)
Pages (from-to)579-583
Number of pages5
JournalScandinavian Journal of Infectious Diseases
Issue number5
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases


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