Enkephalin analogue effects in the amygdala central nucleus on conditioned heart rate

Michela Gallagher, Bruce S. Kapp, Jeffery P. Pascoe

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


The experiment was conducted to assess the effects of enkephalin analogue administration into the amygdala central nucleus on the acquisition of classically conditioned heart rate responding in rabbits. Bilateral injections of either D-Ala2, Met5-enkephalinamide (DALA) or D-Ala2, D-Leu5-enkephalin (DADL) were administered in a 1.0 μl volume into the central nucleus immediately prior to the conditioning session. Administration of DALA significantly attenuated the acquisition of conditioned heart rate responding whereas groups which received comparable doses of DADL exhibited conditioned responding which did not differ from the vehicle-injected control group. The effect on conditioned responding produced by DALA administration was blocked by concurrent administration of the opiate antagonist naloxone. These results provide some support for the involvement of mu receptor activity within the central nucleus region of the amygdala in conditioning processes.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Issue number2
StatePublished - Aug 1982
Externally publishedYes


  • Amygdala central nucleus
  • Enkephalin analogues
  • Heart rate conditioning
  • Opiate receptors
  • Rabbits

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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