Enhancement of the bias component of downbeat nystagmus after lesions of the nodulus and uvula

Mark F. Walker; Jing Tian; Xiaoyan Shan; Howard Ying; Rafael J. Tamargo; David S. Zee

doi:10.1111/j.1749-6632.2008.03717.x

Enhancement of the bias component of downbeat nystagmus after lesions of the nodulus and uvula

Mark F. Walker, Jing Tian, Xiaoyan Shan, Howard Ying, Rafael J. Tamargo, David S. Zee

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

15 Scopus citations

Abstract

In two monkeys, we recorded spontaneous eye movements before and after ablation of the cerebellar nodulus and uvula (Nod/Uv). In both monkeys, there was an increase in upward ocular drift (downbeat nystagmus [DBN]) in darkness (M1: 1.5°/s pre, 3.4°/s post; M2: 1.3°/s pre, 7.0°/s post), but not in light. There was little effect of orbital position on drift velocity. These findings suggest that the Nod/Uv may play a role in the bias component of DBN.

Original language	English (US)
Title of host publication	Basic and Clinical Aspects of Vertigo and Dizziness
Publisher	Blackwell Publishing Inc.
Pages	482-485
Number of pages	4
ISBN (Print)	9781573317177
DOIs	https://doi.org/10.1111/j.1749-6632.2008.03717.x
State	Published - May 2009

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1164
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

Keywords

Ataxia
Cerebellum
Monkey
Oscillopsia
Rhesus

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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10.1111/j.1749-6632.2008.03717.x

Cite this

Walker, M. F., Tian, J., Shan, X., Ying, H., Tamargo, R. J., & Zee, D. S. (2009). Enhancement of the bias component of downbeat nystagmus after lesions of the nodulus and uvula. In Basic and Clinical Aspects of Vertigo and Dizziness (pp. 482-485). (Annals of the New York Academy of Sciences; Vol. 1164). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2008.03717.x

Enhancement of the bias component of downbeat nystagmus after lesions of the nodulus and uvula. / Walker, Mark F.; Tian, Jing; Shan, Xiaoyan et al.
Basic and Clinical Aspects of Vertigo and Dizziness. Blackwell Publishing Inc., 2009. p. 482-485 (Annals of the New York Academy of Sciences; Vol. 1164).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Zee, David S.

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AB - In two monkeys, we recorded spontaneous eye movements before and after ablation of the cerebellar nodulus and uvula (Nod/Uv). In both monkeys, there was an increase in upward ocular drift (downbeat nystagmus [DBN]) in darkness (M1: 1.5°/s pre, 3.4°/s post; M2: 1.3°/s pre, 7.0°/s post), but not in light. There was little effect of orbital position on drift velocity. These findings suggest that the Nod/Uv may play a role in the bias component of DBN.

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KW - Cerebellum

KW - Monkey

KW - Oscillopsia

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Enhancement of the bias component of downbeat nystagmus after lesions of the nodulus and uvula

Abstract

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Keywords

ASJC Scopus subject areas

Access to Document

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