Enhancement of rat heart microsomal lipid peroxidation following doxorubicin treatment in vivo

E. G. Mimnaugh; M. A. Trush; T. E. Gram

Enhancement of rat heart microsomal lipid peroxidation following doxorubicin treatment in vivo

E. G. Mimnaugh, M. A. Trush, T. E. Gram

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Cardiac microsomes from rats injected with doxorubicin (5 mg/kg ip x 3) were susceptible to dramatically enhanced NADPH-dependent lipid peroxidation in the presence of doxorubicin in vitro (18-fold increases over control peroxidation). These results suggest that doxorubicin treatment in vivo caused biochemical alterations which predisposed cardiac microsomal membranes to attack by anthracycline free radical-generated oxyradicals.

Original language	English (US)
Pages (from-to)	731-733
Number of pages	3
Journal	Cancer Treatment Reports
Volume	67
Issue number	7-8
State	Published - Jan 1 1983

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Enhancement of rat heart microsomal lipid peroxidation following doxorubicin treatment in vivo",

abstract = "Cardiac microsomes from rats injected with doxorubicin (5 mg/kg ip x 3) were susceptible to dramatically enhanced NADPH-dependent lipid peroxidation in the presence of doxorubicin in vitro (18-fold increases over control peroxidation). These results suggest that doxorubicin treatment in vivo caused biochemical alterations which predisposed cardiac microsomal membranes to attack by anthracycline free radical-generated oxyradicals.",

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N2 - Cardiac microsomes from rats injected with doxorubicin (5 mg/kg ip x 3) were susceptible to dramatically enhanced NADPH-dependent lipid peroxidation in the presence of doxorubicin in vitro (18-fold increases over control peroxidation). These results suggest that doxorubicin treatment in vivo caused biochemical alterations which predisposed cardiac microsomal membranes to attack by anthracycline free radical-generated oxyradicals.

AB - Cardiac microsomes from rats injected with doxorubicin (5 mg/kg ip x 3) were susceptible to dramatically enhanced NADPH-dependent lipid peroxidation in the presence of doxorubicin in vitro (18-fold increases over control peroxidation). These results suggest that doxorubicin treatment in vivo caused biochemical alterations which predisposed cardiac microsomal membranes to attack by anthracycline free radical-generated oxyradicals.

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Enhancement of rat heart microsomal lipid peroxidation following doxorubicin treatment in vivo

Abstract

ASJC Scopus subject areas

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