TY - JOUR
T1 - Enhanced use of phylogenetic data to inform public health approaches to HIV among men who have sex with men
AU - German, Danielle
AU - Grabowski, Mary Kate
AU - Beyrer, Chris
N1 - Funding Information:
This work was supported by The Johns Hopkins University Center for AIDS Research (1P30AI094189). DG is supported by the National Institutes of Health (K01DA041259). MKG is supported by the National Institutes of Health (K01AI12508601, R01AI11324) and the Bill and Melinda Gates Foundation (OPP1084362).
Publisher Copyright:
© CSIRO 2017.
PY - 2017
Y1 - 2017
N2 - The multidimensional nature and continued evolution of HIV epidemics among men who have sex with men (MSM) requires innovative intervention approaches. Strategies are needed that recognise the individual, social and structural factors driving HIV transmission; that can pinpoint networks with heightened transmission risk; and that can help target intervention in real time. HIV phylogenetics is a rapidly evolving field with strong promise for informing innovative responses to the HIV epidemic among MSM. Currently, HIV phylogenetic insights are providing new understandings of characteristics of HIV epidemics involving MSM, social networks influencing transmission, characteristics of HIV transmission clusters involving MSM, targets for antiretroviral and other prevention strategies and dynamics of emergent epidemics. Maximising the potential of HIV phylogenetics for HIV responses among MSM will require attention to key methodological challenges and ethical considerations, as well as resolving key implementation and scientific questions. Enhanced and integrated use of HIV surveillance, sociobehavioural and phylogenetic data resources are becoming increasingly critical for informing public health approaches to HIV among MSM.
AB - The multidimensional nature and continued evolution of HIV epidemics among men who have sex with men (MSM) requires innovative intervention approaches. Strategies are needed that recognise the individual, social and structural factors driving HIV transmission; that can pinpoint networks with heightened transmission risk; and that can help target intervention in real time. HIV phylogenetics is a rapidly evolving field with strong promise for informing innovative responses to the HIV epidemic among MSM. Currently, HIV phylogenetic insights are providing new understandings of characteristics of HIV epidemics involving MSM, social networks influencing transmission, characteristics of HIV transmission clusters involving MSM, targets for antiretroviral and other prevention strategies and dynamics of emergent epidemics. Maximising the potential of HIV phylogenetics for HIV responses among MSM will require attention to key methodological challenges and ethical considerations, as well as resolving key implementation and scientific questions. Enhanced and integrated use of HIV surveillance, sociobehavioural and phylogenetic data resources are becoming increasingly critical for informing public health approaches to HIV among MSM.
KW - HIV prevention and intervention
KW - molecular surveillance
KW - viral sequence data.
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U2 - 10.1071/SH16056
DO - 10.1071/SH16056
M3 - Review article
C2 - 27584826
AN - SCOPUS:85012249756
SN - 1448-5028
VL - 14
SP - 89
EP - 96
JO - Sexual Health
JF - Sexual Health
IS - 1
ER -