Enhanced production of human immunodeficiency virus type 1 by in vitro-infected alveolar macrophages from otherwise healthy cigarette smokers

Rita A. Abbud; Candace K. Finegan; Laura A. Guay; Elizabeth A. Rich

doi:10.1093/infdis/172.3.859

Enhanced production of human immunodeficiency virus type 1 by in vitro-infected alveolar macrophages from otherwise healthy cigarette smokers

Rita A. Abbud, Candace K. Finegan, Laura A. Guay, Elizabeth A. Rich

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Since cellular activation is required for replication of human immunodeficiency virus type 1 (HIV-1), the capacity of alveolar macrophages (AM) from smokers, which are relatively activated, and nonsmokers to support the production of HIV-1_JR-FLwas examined. Peak HIV-1 p24 antigen level in culture supernatants of infected AM from 13 smokers was significantly higher than that of 13 nonsmokers: 31, 394 ± 8295 versus 7037 ± 2550 pg/mL (mean ± SE; p

Original language	English (US)
Pages (from-to)	859-863
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	172
Issue number	3
DOIs	https://doi.org/10.1093/infdis/172.3.859
State	Published - 1995
Externally published	Yes

ASJC Scopus subject areas

Infectious Diseases
Immunology and Allergy
Immunology
Public Health, Environmental and Occupational Health

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10.1093/infdis/172.3.859

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AU - Guay, Laura A.

AU - Rich, Elizabeth A.

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Enhanced production of human immunodeficiency virus type 1 by in vitro-infected alveolar macrophages from otherwise healthy cigarette smokers

Abstract

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