Enhanced chemiluminescence of phagocytic cells from rats treated with chlorphentermine

Michael A. Trush; Michael J. McNulty; Mark J. Reasor

doi:10.1016/0378-4274(79)90020-1

Enhanced chemiluminescence of phagocytic cells from rats treated with chlorphentermine

Michael A. Trush, Michael J. McNulty, Mark J. Reasor

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The chronic administration of chlorphentermine to rats resulted in the appearance of enlarged, foamy alveolar macrophages (AMs) m the alveoli of the lungs. Circulating polymorphonuclear leukocytes (PMNs) from treated rats did not show a change in size. When challenged with unopsonized zymosan, the chemiluminescence (CL) of AMs from treated rats was enhanced with the peak response occurring later than with control AMs. Opsonization of the zymosan led to a further increase in CL from the foamy AMs while having no effect with control AMs. PMNs from treated rats also gave an enhanced CL response when compared to PMNs from control rats.

Original language	English (US)
Pages (from-to)	185-190
Number of pages	6
Journal	Toxicology Letters
Volume	3
Issue number	3
DOIs	https://doi.org/10.1016/0378-4274(79)90020-1
State	Published - Mar 1979

ASJC Scopus subject areas

Toxicology

Access to Document

10.1016/0378-4274(79)90020-1

Cite this

@article{3bab40b199704e2da857ae60ff593b78,

title = "Enhanced chemiluminescence of phagocytic cells from rats treated with chlorphentermine",

abstract = "The chronic administration of chlorphentermine to rats resulted in the appearance of enlarged, foamy alveolar macrophages (AMs) m the alveoli of the lungs. Circulating polymorphonuclear leukocytes (PMNs) from treated rats did not show a change in size. When challenged with unopsonized zymosan, the chemiluminescence (CL) of AMs from treated rats was enhanced with the peak response occurring later than with control AMs. Opsonization of the zymosan led to a further increase in CL from the foamy AMs while having no effect with control AMs. PMNs from treated rats also gave an enhanced CL response when compared to PMNs from control rats.",

author = "Trush, {Michael A.} and McNulty, {Michael J.} and Reasor, {Mark J.}",

note = "Funding Information: This researchw as supported by NIH Training Grant T32 GM 07039, a West Virginia University Senate Grant and a PMA Foundation Research Starter Grant. The authors thank Warner-Chilcott for their generousg ift of chlorphentermine.",

year = "1979",

month = mar,

doi = "10.1016/0378-4274(79)90020-1",

language = "English (US)",

volume = "3",

pages = "185--190",

journal = "Toxicology Letters",

issn = "0378-4274",

publisher = "Elsevier BV",

number = "3",

}

TY - JOUR

T1 - Enhanced chemiluminescence of phagocytic cells from rats treated with chlorphentermine

AU - Trush, Michael A.

AU - McNulty, Michael J.

AU - Reasor, Mark J.

N1 - Funding Information: This researchw as supported by NIH Training Grant T32 GM 07039, a West Virginia University Senate Grant and a PMA Foundation Research Starter Grant. The authors thank Warner-Chilcott for their generousg ift of chlorphentermine.

PY - 1979/3

Y1 - 1979/3

N2 - The chronic administration of chlorphentermine to rats resulted in the appearance of enlarged, foamy alveolar macrophages (AMs) m the alveoli of the lungs. Circulating polymorphonuclear leukocytes (PMNs) from treated rats did not show a change in size. When challenged with unopsonized zymosan, the chemiluminescence (CL) of AMs from treated rats was enhanced with the peak response occurring later than with control AMs. Opsonization of the zymosan led to a further increase in CL from the foamy AMs while having no effect with control AMs. PMNs from treated rats also gave an enhanced CL response when compared to PMNs from control rats.

AB - The chronic administration of chlorphentermine to rats resulted in the appearance of enlarged, foamy alveolar macrophages (AMs) m the alveoli of the lungs. Circulating polymorphonuclear leukocytes (PMNs) from treated rats did not show a change in size. When challenged with unopsonized zymosan, the chemiluminescence (CL) of AMs from treated rats was enhanced with the peak response occurring later than with control AMs. Opsonization of the zymosan led to a further increase in CL from the foamy AMs while having no effect with control AMs. PMNs from treated rats also gave an enhanced CL response when compared to PMNs from control rats.

UR - http://www.scopus.com/inward/record.url?scp=0018341172&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018341172&partnerID=8YFLogxK

U2 - 10.1016/0378-4274(79)90020-1

DO - 10.1016/0378-4274(79)90020-1

M3 - Article

AN - SCOPUS:0018341172

SN - 0378-4274

VL - 3

SP - 185

EP - 190

JO - Toxicology Letters

JF - Toxicology Letters

IS - 3

ER -

Enhanced chemiluminescence of phagocytic cells from rats treated with chlorphentermine

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this