Enhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates

R. Sanchez-Pernaute; J. Q. Wang; D. Kuruppu; L. Cao; W. Tueckmantel; A. Kozikowski; O. Isacson; A. L. Brownell

doi:10.1016/j.neuroimage.2008.04.170

Enhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates

R. Sanchez-Pernaute
, J. Q. Wang
, D. Kuruppu
, L. Cao
, W. Tueckmantel
, A. Kozikowski
, O. Isacson
, A. L. Brownell

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

The interplay between dopamine and glutamate in the basal ganglia regulates critical aspects of motor learning and behavior. Metabotropic glutamate receptors (mGluR) are increasingly regarded as key modulators of neuroadaptation in these circuits, in normal and disease conditions. Using PET, we demonstrate a significant upregulation of mGluR type 5 in the striatum of MPTP-lesioned, parkinsonian primates, providing the basis for therapeutic exploration of mGluR5 antagonists in Parkinson disease.

Original language	English (US)
Pages (from-to)	248-251
Number of pages	4
Journal	NeuroImage
Volume	42
Issue number	1
DOIs	https://doi.org/10.1016/j.neuroimage.2008.04.170
State	Published - Aug 1 2008
Externally published	Yes

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience

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title = "Enhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates",

abstract = "The interplay between dopamine and glutamate in the basal ganglia regulates critical aspects of motor learning and behavior. Metabotropic glutamate receptors (mGluR) are increasingly regarded as key modulators of neuroadaptation in these circuits, in normal and disease conditions. Using PET, we demonstrate a significant upregulation of mGluR type 5 in the striatum of MPTP-lesioned, parkinsonian primates, providing the basis for therapeutic exploration of mGluR5 antagonists in Parkinson disease.",

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note = "Funding Information: Supported by NIH-1R01 EB001850 and NIH-1P50 NS39793. We are grateful to Jack McDowell for the technical support and Dr BG Jenkins for the MRI studies.",

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AU - Sanchez-Pernaute, R.

AU - Wang, J. Q.

AU - Kuruppu, D.

AU - Cao, L.

AU - Tueckmantel, W.

AU - Kozikowski, A.

AU - Isacson, O.

AU - Brownell, A. L.

N1 - Funding Information: Supported by NIH-1R01 EB001850 and NIH-1P50 NS39793. We are grateful to Jack McDowell for the technical support and Dr BG Jenkins for the MRI studies.

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AB - The interplay between dopamine and glutamate in the basal ganglia regulates critical aspects of motor learning and behavior. Metabotropic glutamate receptors (mGluR) are increasingly regarded as key modulators of neuroadaptation in these circuits, in normal and disease conditions. Using PET, we demonstrate a significant upregulation of mGluR type 5 in the striatum of MPTP-lesioned, parkinsonian primates, providing the basis for therapeutic exploration of mGluR5 antagonists in Parkinson disease.

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Enhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates

Abstract

ASJC Scopus subject areas

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