Engineering approaches for effective therapeutic applications based on extracellular vesicles

Seunglee Kwon, Sol Shin, Minjae Do, Byeong Hoon Oh, Yeari Song, Van Dat Bui, Eun Sook Lee, Dong Gyu Jo, Yong Woo Cho, Deok Ho Kim, Jae Hyung Park

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The biological significance of extracellular vesicles (EVs) as intercellular communication mediators has been increasingly revealed in a wide range of normal physiological processes and disease pathogenesis. In particular, regenerative and immunomodulatory EVs hold potential as innate biotherapeutics, whereas pathological EVs are considered therapeutic targets for inhibiting their bioactivity. Given their ability to transport functional cargos originating from the source cells to target cells, EVs can also be used as a therapeutic means to deliver drug molecules. This review aims to provide an updated overview of the key engineering approaches for better exploiting EVs in disease intervention. The emphasis is lying on the preconditioning methods for therapeutic EVs, drug loading and targeting technologies for carrier EVs, and activity control strategies for pathological EVs.

Original languageEnglish (US)
Pages (from-to)15-30
Number of pages16
JournalJournal of Controlled Release
Volume330
DOIs
StatePublished - Feb 10 2021

Keywords

  • Biogenesis inhibition
  • Drug loading
  • Extracellular vesicles
  • Preconditioning
  • Surface modification
  • Therapeutic applications

ASJC Scopus subject areas

  • Pharmaceutical Science

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