Endoscopic Transoral Approach for Resection of Basal Cell Adenoma Arising in Parapharyngeal Space

Lifeng Li, Nyall R. London, Shuling Li, Xiaohong Chen, Ricardo L. Carrau

Research output: Contribution to journalArticlepeer-review


Objectives: The clinical and radiological characteristics of the basal cell adenoma (BCA) and its association with the internal carotid artery (ICA) in the parapharyngeal space (PPS), have not been sufficiently explored. This study aims to analyze the characteristics of patients with BCA arising in the PPS and to evaluate the feasibility of a total resection via an endoscopic transoral corridor. Design and Main Outcome Measures: The clinical, radiological, and histopathological characteristics of four patients with BCA arising in the PPS were retrospectively analyzed. The endoscopic transoral approach was performed for resection of BCA. Its technical nuances, perioperative comorbidities, and outcomes are introduced. Results: The clinical presentation, symptoms, and signs of patients with BCA are variable. The tumor was lateral to the ICA in two patients and anterior to the ICA in the remaining two. All four BCA were successfully removed en bloc (n = 3) or by piecemeal (n = 1) via an endoscopic transoral approach. The ICA was not injured, and no additional nerve damage, venous bleeding, postoperative infection, or salivary gland fistula were encountered in any of the four patients. Cystic degeneration is the predominant appearance of BCA on MRI; however, they are difficult to differentiate from other lesions arising in the PPS. No recurrence was detected at the time of the study analysis. Conclusion: BCA of the PPS could have variable relationships with the ICA. An endoscopic transoral approach can provide an adequate corridor for total resection of BCA in PPS with seemingly low morbidity.

Original languageEnglish (US)
JournalJournal of Neurological Surgery, Part B: Skull Base
StateAccepted/In press - 2020


  • basal cell adenoma
  • endoscopic
  • parapharyngeal space
  • resection
  • retro-styloid space
  • transoral

ASJC Scopus subject areas

  • Clinical Neurology


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