Endoscopic optical coherence tomography: Technologies and clinical applications [invited]

Michalina J. Gora, Melissa J. Suter, Guillermo J. Tearney, Xingde Li

Research output: Contribution to journalReview articlepeer-review

121 Scopus citations


In this paper, we review the current state of technology development and clinical applications of endoscopic optical coherence tomography (OCT). Key design and engineering considerations are discussed for most OCT endoscopes, including side-viewing and forward-viewing probes, along with different scanning mechanisms (proximal-scanning versus distal-scanning). Multi-modal endoscopes that integrate OCT with other imaging modalities are also discussed. The review of clinical applications of endoscopic OCT focuses heavily on diagnosis of diseases and guidance of interventions. Representative applications in several organ systems are presented, such as in the cardiovascular, digestive, respiratory, and reproductive systems. A brief outlook of the field of endoscopic OCT is also discussed.

Original languageEnglish (US)
Pages (from-to)2405-2444
Number of pages40
JournalBiomedical Optics Express
Issue number5
StatePublished - May 1 2017


  • Clinical applications
  • Endoscopic imaging
  • Optical coherence tomography
  • Optical diagnostics for medicine

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics


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