Endometrial pathology and estrogens

Zev Rosenwaks, Anne C. Wentz, Georgeanna Seegar Jones, Maria D. Urban, Peter A. Lee, Claude J. Migeon, Tim H. Parmley, J. Donald Woodruff

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Endometrial biopsies were obtained from 46 hypogonadal patients (44 with gonadal dysgenesis; 2 panhypopituitary) who were receiving estrogen-progestogen therapy. Endometrial abnormalities occurred only in patients receiving a total lifetime conjugated estrogen dose of ≥2500 mg and who had received estrogen treatment for a period longer than 4.2 years. The biopsy outcome was significantly related (P<0.01) to the estrogen dose at time of biopsy and to the total lifetime dose (P<0.05). The progestational drugs administered did not protect against development of endometrial abnormalities. None of the abnormal endometrial patterns were associated with abnormal vaginal bleeding.

Original languageEnglish (US)
Pages (from-to)403-410
Number of pages8
JournalObstetrics and gynecology
Issue number4
StatePublished - Apr 1979

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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