Endogenous sex hormone changes in postmenopausal women in the diabetes prevention program

Catherine Kim, Shengchun Kong, Gail A. Laughlin, Sherita H. Golden, Kieren J. Mather, Bin Nan, Sharon L. Edelstein, John F. Randolph, Fernand Labrie, Elizabeth Buschur, Elizabeth Barrett-Connor

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Context: Whether endogenous sex hormones (ESH) [SHBG, estradiol, testosterone, and dehydroepiandrosterone (DHEA)] are altered by intensive lifestyle modification (ILS) or metformin and whether such changes affect glucose levels among dysglycemic postmenopausalwomenis unclear. Objectives: Our objective was to examine intervention impact on ESH and associations with fasting plasma glucose (FPG) and 2-h glucose changes among postmenopausal glucose-intolerant women. Design: We performed a secondary analysis of a randomized controlled trial. Participants: Participants included postmenopausal, overweight, glucose-intolerant women not using exogenous estrogen (n = 382) who participated in the Diabetes Prevention Program. Interventions: Interventions included ILS with the goals of weight reduction of at least 7% of initial weight and 150 min/wk of moderate intensity exercise or metformin or placebo administered 850 mg twice a day. Main Outcome Measures: Intervention-related changes in ESH and associations of changes in ESH and glucose levels were evaluated. Results: ILS significantly increased SHBG and decreased DHEA beforeandafter adjustment for changes in waist circumference and fasting insulin. ILS did not alter estradiol or testosterone.Metformindid not change any ESH. ILS-induced increases in SHBG and declines in DHEA were associated with decreases in FPG and 2-h glucose, and declines in estradiol were associated with decreases in FPG, before and after adjustment for age, FSH, race/ethnicity, changes in waist circumference, and 1/fasting insulin. Conclusions: Among postmenopausal glucose-intolerant women not using estrogen, ILS increased SHBG levels and lowered DHEA levels. These changes were associated with lower glucose independent of adiposity and insulin. Metformin effects upon ESH were not significant.

Original languageEnglish (US)
Pages (from-to)2853-2861
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Issue number8
StatePublished - Aug 2012

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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