Endogenous opioid regulation of hypothalamo-pituitary-adrenal axis activity in schizophrenia

Owen M. Wolkowitz; Allen R. Doran; Alan Breier; Martin R. Cohen; David Pickar

doi:10.1016/0006-3223(86)90164-2

Endogenous opioid regulation of hypothalamo-pituitary-adrenal axis activity in schizophrenia

Owen M. Wolkowitz, Allen R. Doran, Alan Breier, Martin R. Cohen, David Pickar

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We utilized a naloxone challenge strategy to investigate the functioning of the endogenous opioid system (EOS) in schizophrenia. Patients with schizophrenia, who were on neuroleptic medication or drug-free, demonstrated a significantly larger serum cortisol response to opioid blockade by naloxone than did age- and sex-matched normal controls. Patients, but not normal controls, also demonstrated an inverse relationship between baseline cortisol and the magnitude of the response. This enhanced cortisol response is consistent with tonic hyperactivity of the EOS in schizophrenia.

Original language	English (US)
Pages (from-to)	366-373
Number of pages	8
Journal	Biological Psychiatry
Volume	21
Issue number	4
DOIs	https://doi.org/10.1016/0006-3223(86)90164-2
State	Published - 1986
Externally published	Yes

ASJC Scopus subject areas

Biological Psychiatry

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abstract = "We utilized a naloxone challenge strategy to investigate the functioning of the endogenous opioid system (EOS) in schizophrenia. Patients with schizophrenia, who were on neuroleptic medication or drug-free, demonstrated a significantly larger serum cortisol response to opioid blockade by naloxone than did age- and sex-matched normal controls. Patients, but not normal controls, also demonstrated an inverse relationship between baseline cortisol and the magnitude of the response. This enhanced cortisol response is consistent with tonic hyperactivity of the EOS in schizophrenia.",

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AU - Cohen, Martin R.

AU - Pickar, David

PY - 1986

Y1 - 1986

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AB - We utilized a naloxone challenge strategy to investigate the functioning of the endogenous opioid system (EOS) in schizophrenia. Patients with schizophrenia, who were on neuroleptic medication or drug-free, demonstrated a significantly larger serum cortisol response to opioid blockade by naloxone than did age- and sex-matched normal controls. Patients, but not normal controls, also demonstrated an inverse relationship between baseline cortisol and the magnitude of the response. This enhanced cortisol response is consistent with tonic hyperactivity of the EOS in schizophrenia.

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Endogenous opioid regulation of hypothalamo-pituitary-adrenal axis activity in schizophrenia

Abstract

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