Endogenous neurosteroid synthesis modulates seizure frequency

Courtney Lawrence; Brandon Scott Martin; Chengsan Sun; John Williamson; Jaideep Kapur

doi:10.1002/ana.21989

Endogenous neurosteroid synthesis modulates seizure frequency

Courtney Lawrence, Brandon Scott Martin, Chengsan Sun, John Williamson, Jaideep Kapur

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Inhibitory neurosteroids, molecules generated in glia from circulating steroid hormones and de novo from cholesterol, keep seizures in check in epileptic animals. They can enhance inhibitory transmission mediated by gamma-aminobutyric acid receptors and have anticonvulsant action.

Original language	English (US)
Pages (from-to)	689-693
Number of pages	5
Journal	Annals of neurology
Volume	67
Issue number	5
DOIs	https://doi.org/10.1002/ana.21989
State	Published - May 2010
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/ana.21989

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title = "Endogenous neurosteroid synthesis modulates seizure frequency",

abstract = "Inhibitory neurosteroids, molecules generated in glia from circulating steroid hormones and de novo from cholesterol, keep seizures in check in epileptic animals. They can enhance inhibitory transmission mediated by gamma-aminobutyric acid receptors and have anticonvulsant action.",

author = "Courtney Lawrence and Martin, {Brandon Scott} and Chengsan Sun and John Williamson and Jaideep Kapur",

year = "2010",

month = may,

doi = "10.1002/ana.21989",

language = "English (US)",

volume = "67",

pages = "689--693",

journal = "Annals of neurology",

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T1 - Endogenous neurosteroid synthesis modulates seizure frequency

AU - Lawrence, Courtney

AU - Martin, Brandon Scott

AU - Sun, Chengsan

AU - Williamson, John

AU - Kapur, Jaideep

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Y1 - 2010/5

N2 - Inhibitory neurosteroids, molecules generated in glia from circulating steroid hormones and de novo from cholesterol, keep seizures in check in epileptic animals. They can enhance inhibitory transmission mediated by gamma-aminobutyric acid receptors and have anticonvulsant action.

AB - Inhibitory neurosteroids, molecules generated in glia from circulating steroid hormones and de novo from cholesterol, keep seizures in check in epileptic animals. They can enhance inhibitory transmission mediated by gamma-aminobutyric acid receptors and have anticonvulsant action.

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JO - Annals of neurology

JF - Annals of neurology

IS - 5

ER -

Endogenous neurosteroid synthesis modulates seizure frequency

Abstract

ASJC Scopus subject areas

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