Endogenous bufadienolide mediates pressor response to ethanol withdrawal in rats

Vladimir A. Kashkin; Edwin E. Zvartau; Olga V. Fedorova; Yakov Y. Bagrov; Edward G. Lakatta; Alexei Y. Bagrov

doi:10.1016/j.euroneuro.2007.05.006

Endogenous bufadienolide mediates pressor response to ethanol withdrawal in rats

Vladimir A. Kashkin, Edwin E. Zvartau, Olga V. Fedorova, Yakov Y. Bagrov, Edward G. Lakatta, Alexei Y. Bagrov

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

An endogenous natriuretic and vasoconstrictor Na/K-ATPase inhibitor, marinobufagenin (MBG), is implicated in NaCl-induced hypertension and in ethanol addiction. In rats, MBG suppresses voluntary alcohol intake, while immunization against MBG induces alcohol-seeking behavior. Since alcohol withdrawal is associated with elevation of blood pressure (BP) and renal sodium retention, we hypothesized that MBG mediates pressor response to ethanol withdrawal. In male Sprague-Dawley rats, forced ethanol intake (20% v/v, 2.8 ± 0.2 g/day for 7 days) did not affect BP and MBG excretion. Ethanol withdrawal was associated with a 21 mm Hg increase in BP, a 10% decrease in hematocrit, and a three-fold increase in renal MBG excretion. In vivo administration of anti-MBG antibody to rats prevented withdrawal-induced BP elevation. Therefore, MBG mediates pressor response to ethanol withdrawal, and may link mechanisms of ethanol dependence and hypertension.

Original language	English (US)
Pages (from-to)	74-77
Number of pages	4
Journal	European Neuropsychopharmacology
Volume	18
Issue number	1
DOIs	https://doi.org/10.1016/j.euroneuro.2007.05.006
State	Published - Jan 2008
Externally published	Yes

Keywords

Ethanol
Hypertension
Marinobufagenin
Na/K-ATPase
NaCl sensitivity
Rat
Withdrawal

ASJC Scopus subject areas

Pharmacology
Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry
Pharmacology (medical)

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title = "Endogenous bufadienolide mediates pressor response to ethanol withdrawal in rats",

abstract = "An endogenous natriuretic and vasoconstrictor Na/K-ATPase inhibitor, marinobufagenin (MBG), is implicated in NaCl-induced hypertension and in ethanol addiction. In rats, MBG suppresses voluntary alcohol intake, while immunization against MBG induces alcohol-seeking behavior. Since alcohol withdrawal is associated with elevation of blood pressure (BP) and renal sodium retention, we hypothesized that MBG mediates pressor response to ethanol withdrawal. In male Sprague-Dawley rats, forced ethanol intake (20% v/v, 2.8 ± 0.2 g/day for 7 days) did not affect BP and MBG excretion. Ethanol withdrawal was associated with a 21 mm Hg increase in BP, a 10% decrease in hematocrit, and a three-fold increase in renal MBG excretion. In vivo administration of anti-MBG antibody to rats prevented withdrawal-induced BP elevation. Therefore, MBG mediates pressor response to ethanol withdrawal, and may link mechanisms of ethanol dependence and hypertension.",

keywords = "Ethanol, Hypertension, Marinobufagenin, Na/K-ATPase, NaCl sensitivity, Rat, Withdrawal",

author = "Kashkin, {Vladimir A.} and Zvartau, {Edwin E.} and Fedorova, {Olga V.} and Bagrov, {Yakov Y.} and Lakatta, {Edward G.} and Bagrov, {Alexei Y.}",

note = "Funding Information: The experiments described in this paper were supported by the National Institute on Aging, National Institutes of Health Intramural Research Program and by Russian Foundation for Fundamental Science (grant 06-04-48956). ",

year = "2008",

month = jan,

doi = "10.1016/j.euroneuro.2007.05.006",

language = "English (US)",

volume = "18",

pages = "74--77",

journal = "European Neuropsychopharmacology",

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T1 - Endogenous bufadienolide mediates pressor response to ethanol withdrawal in rats

AU - Kashkin, Vladimir A.

AU - Zvartau, Edwin E.

AU - Fedorova, Olga V.

AU - Bagrov, Yakov Y.

AU - Lakatta, Edward G.

AU - Bagrov, Alexei Y.

N1 - Funding Information: The experiments described in this paper were supported by the National Institute on Aging, National Institutes of Health Intramural Research Program and by Russian Foundation for Fundamental Science (grant 06-04-48956).

PY - 2008/1

Y1 - 2008/1

N2 - An endogenous natriuretic and vasoconstrictor Na/K-ATPase inhibitor, marinobufagenin (MBG), is implicated in NaCl-induced hypertension and in ethanol addiction. In rats, MBG suppresses voluntary alcohol intake, while immunization against MBG induces alcohol-seeking behavior. Since alcohol withdrawal is associated with elevation of blood pressure (BP) and renal sodium retention, we hypothesized that MBG mediates pressor response to ethanol withdrawal. In male Sprague-Dawley rats, forced ethanol intake (20% v/v, 2.8 ± 0.2 g/day for 7 days) did not affect BP and MBG excretion. Ethanol withdrawal was associated with a 21 mm Hg increase in BP, a 10% decrease in hematocrit, and a three-fold increase in renal MBG excretion. In vivo administration of anti-MBG antibody to rats prevented withdrawal-induced BP elevation. Therefore, MBG mediates pressor response to ethanol withdrawal, and may link mechanisms of ethanol dependence and hypertension.

AB - An endogenous natriuretic and vasoconstrictor Na/K-ATPase inhibitor, marinobufagenin (MBG), is implicated in NaCl-induced hypertension and in ethanol addiction. In rats, MBG suppresses voluntary alcohol intake, while immunization against MBG induces alcohol-seeking behavior. Since alcohol withdrawal is associated with elevation of blood pressure (BP) and renal sodium retention, we hypothesized that MBG mediates pressor response to ethanol withdrawal. In male Sprague-Dawley rats, forced ethanol intake (20% v/v, 2.8 ± 0.2 g/day for 7 days) did not affect BP and MBG excretion. Ethanol withdrawal was associated with a 21 mm Hg increase in BP, a 10% decrease in hematocrit, and a three-fold increase in renal MBG excretion. In vivo administration of anti-MBG antibody to rats prevented withdrawal-induced BP elevation. Therefore, MBG mediates pressor response to ethanol withdrawal, and may link mechanisms of ethanol dependence and hypertension.

KW - Ethanol

KW - Hypertension

KW - Marinobufagenin

KW - Na/K-ATPase

KW - NaCl sensitivity

KW - Rat

KW - Withdrawal

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Endogenous bufadienolide mediates pressor response to ethanol withdrawal in rats

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